Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06615531
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-23
Brief Title:
Integrating Magnetic Imaging With Rich Phenotypes
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Meditation on Human Well Being
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IMAGINE
Brief Summary:
This study will be focused on assessing the molecular physiological neuroimaging and emotional correlates of a week-long intensive meditation retreat experience in a 20-person cohort comprised of healthy participants
Detailed Description:
Mind-body interventions including meditation reconceptualization and placebo have been shown to improve a broad range of physical and mental health outcomes in both healthy and patient populations How and what humans think about their health has a significant and quantifiable impact
Placebo effects another mind-body technique that creates health improvements have been shown to impact every major organ system More recently open-label placebos placebos administered without concealment such that the subject is aware of the placebo have been shown to be effective for a host of health conditions Open-label placebo effects demonstrate that placebo responses are surprisingly not dependent on deception positive expectation or conditioning
Meditation yet another mind-body intervention has been shown to reduce pain inflammation stress anxiety depression and to improve immune function and emotional regulation Different meditation techniques can produce mystical-type experiences-non-ordinary perceptual cognitive and affective states in which the distinction between the perceiver and the perceived is transcended The specific pathways through which meditation promotes physical and mental health are not yet well understood but meditation-induced changes in neural activity and on the immune and autonomic nervous systems as well as meditation-induced molecular changes in gene expression and on the proteome and metabolome suggest that these are both broad and profound
While each of these mind-body interventions has been studied individually the combination of meditation reconceptualization and open label placebo and their combined effect on health neural activity and molecular physiology have never been jointly studied This exploratory observational study will employ psychometric health questionnaires functional magnetic resonance imaging fMRI quantitative electroencephalography qEEG and blood plasma-based real time cell metabolic analysis quantitative assessment of neurite outgrowth and high-throughput transcriptomics proteomics and metabolomics to investigate the joint neural and biological effects of these three mind-body interventions in a 7-day retreat setting
Placebo effects another mind-body technique that creates health improvements have been shown to impact every major organ system More recently open-label placebos placebos administered without concealment such that the subject is aware of the placebo have been shown to be effective for a host of health conditions Open-label placebo effects demonstrate that placebo responses are surprisingly not dependent on deception positive expectation or conditioning
Meditation yet another mind-body intervention has been shown to reduce pain inflammation stress anxiety depression and to improve immune function and emotional regulation Different meditation techniques can produce mystical-type experiences-non-ordinary perceptual cognitive and affective states in which the distinction between the perceiver and the perceived is transcended The specific pathways through which meditation promotes physical and mental health are not yet well understood but meditation-induced changes in neural activity and on the immune and autonomic nervous systems as well as meditation-induced molecular changes in gene expression and on the proteome and metabolome suggest that these are both broad and profound
While each of these mind-body interventions has been studied individually the combination of meditation reconceptualization and open label placebo and their combined effect on health neural activity and molecular physiology have never been jointly studied This exploratory observational study will employ psychometric health questionnaires functional magnetic resonance imaging fMRI quantitative electroencephalography qEEG and blood plasma-based real time cell metabolic analysis quantitative assessment of neurite outgrowth and high-throughput transcriptomics proteomics and metabolomics to investigate the joint neural and biological effects of these three mind-body interventions in a 7-day retreat setting
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None