Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06613256
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-18
Brief Title:
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
JEDI-2
Brief Summary:
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery
The main question we plan to answer is What molecular pathways are differentially expressed during inflammatory pathologies
The main question we plan to answer is What molecular pathways are differentially expressed during inflammatory pathologies
Detailed Description:
The immune system is a complex network of cells and molecules that protects the body from infection and injury When the immune system is activated it produces inflammation which is a natural response to help heal the body However too much inflammation can be harmful and lead to serious complications such as sepsis low blood pressure organ failure and death
The interaction of cells that line the blood vessels endothelial cells EC with the immune system is believed to be the root cause of these symptoms When exposed to inflammation the instructional molecules RNA inside the EC change This leads to a change of operation promoting the severe symptoms previously mentioned
Researchers have developed new safe techniques to collect these cells from the blood vessels of patients to study disorders like diabetes heart disease and stroke This technique involves gently inserting a metal guidewire into an arm vein to collect ECs
This study plans to collect ECs from patients undergoing surgery or admitted to intensive care We also plan to collect control samples from healthy volunteers Samples will be collected over the duration of the patients to RSFT The RNA will be removed from the cells and counted to highlight changes in instructions in the cells
Data from this study will potentially highlight new pathways involved in inflammation and help classify how some patients will react to current treatments To obtain this data this study will be split into 2 parts Part 1 focuses on collecting one sample from a patient when they are at their most unwell states and comparing that to a sample from a healthy person Part 2 will focus on key mRNA molecules identified during Part 1 and identifying how their expression changes over time
The interaction of cells that line the blood vessels endothelial cells EC with the immune system is believed to be the root cause of these symptoms When exposed to inflammation the instructional molecules RNA inside the EC change This leads to a change of operation promoting the severe symptoms previously mentioned
Researchers have developed new safe techniques to collect these cells from the blood vessels of patients to study disorders like diabetes heart disease and stroke This technique involves gently inserting a metal guidewire into an arm vein to collect ECs
This study plans to collect ECs from patients undergoing surgery or admitted to intensive care We also plan to collect control samples from healthy volunteers Samples will be collected over the duration of the patients to RSFT The RNA will be removed from the cells and counted to highlight changes in instructions in the cells
Data from this study will potentially highlight new pathways involved in inflammation and help classify how some patients will react to current treatments To obtain this data this study will be split into 2 parts Part 1 focuses on collecting one sample from a patient when they are at their most unwell states and comparing that to a sample from a healthy person Part 2 will focus on key mRNA molecules identified during Part 1 and identifying how their expression changes over time
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None