Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06612385
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-09
Brief Title:
Significance of Platelet Indices and Ratios in Different Degrees of Burn
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Significance of Platelet Indices and Ratios in Different Degrees of Burn
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Study the correlation between the platelet indices and different degrees of burn Study the correlation between the platelet ratios and different degrees of burn
Detailed Description:
Burns are a major traumatic pathology characterized by tissue destruction and cellular degradation resulted by energy transfer and mainly affect skin which serve as significant cause of morbidity and mortality burns are classified as firstsecond and third degree depending on how deep and severe they penetrate the skin surface
Platelets play important role in primary homeostasis thrombosis inflammation and tissue regulation in the processes of wound healing Platelets can contact exposed collagen and extra cellular matrix and releasing clotting factors to achieve homeostasis as well as essential growth factors and cytokines to repair the woundIn clinical Platelet-rich plasma PRP is a concentrate of autologous plateletshas been used to effectively accelerate burn wound healing Platelet indices PI markers of platelet activation are parameters obtained daily as a part of an automatic blood count Platelet indices are related to platelets morphology and proliferation kinetics Most commonly assessed platelet indices include the mean platelet volume MPV mean distribution widthPDWPlatelet larger cell ratio PLCR platelet crit PCT mean platelet mass MPMmean platelet component MPCPlatelet component distribution width PCDW and immature platelet fraction IPF
The ratio of red blood cell distribution width RWD and platelet PLT RPR is considered an inflammation biomarker associated with the poor prognosis of number of diseases There is two studies about PRP related to prognosis of major burn injury results indicate that RPR-as an inflammatory index- can be used as a biomarker for prognosis of adult patients with major burn injuries
Blood-based platelet parameters due to their fairly easy accessibility and inexpensive methods of measurement seem to be on the rise as potential novel biomarkers of numerous both acute and chronic disease However To date there are no data on the significance of platelets indices in evaluation with different degrees of burn In this study we will evaluate the significance of platelet ratios and indices in different degrees of burn
Platelets play important role in primary homeostasis thrombosis inflammation and tissue regulation in the processes of wound healing Platelets can contact exposed collagen and extra cellular matrix and releasing clotting factors to achieve homeostasis as well as essential growth factors and cytokines to repair the woundIn clinical Platelet-rich plasma PRP is a concentrate of autologous plateletshas been used to effectively accelerate burn wound healing Platelet indices PI markers of platelet activation are parameters obtained daily as a part of an automatic blood count Platelet indices are related to platelets morphology and proliferation kinetics Most commonly assessed platelet indices include the mean platelet volume MPV mean distribution widthPDWPlatelet larger cell ratio PLCR platelet crit PCT mean platelet mass MPMmean platelet component MPCPlatelet component distribution width PCDW and immature platelet fraction IPF
The ratio of red blood cell distribution width RWD and platelet PLT RPR is considered an inflammation biomarker associated with the poor prognosis of number of diseases There is two studies about PRP related to prognosis of major burn injury results indicate that RPR-as an inflammatory index- can be used as a biomarker for prognosis of adult patients with major burn injuries
Blood-based platelet parameters due to their fairly easy accessibility and inexpensive methods of measurement seem to be on the rise as potential novel biomarkers of numerous both acute and chronic disease However To date there are no data on the significance of platelets indices in evaluation with different degrees of burn In this study we will evaluate the significance of platelet ratios and indices in different degrees of burn
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None