Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06611774
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-09
Brief Title:
Metabolic Syndrome in Patients with Knee Osteoarthritis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Metabolic Syndrome in Patients with Knee Osteoarthritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Study the prevalence of metabolic syndrome in patients with knee osteoarthritis and conclude the relationship between metabolic syndrome and the severity of knee osteoarthritis
Detailed Description:
Osteoarthritis is one of the most common clinical conditions causing severe chronic and restrictive disability especially in elderly people
Of those aged 60 years and older 10 of men and 13 of women had symptomatic knee OA As the population ages and the prevalence of obesity and overweight generaly rises the percentage of persons affected with symptomatic knee OA will likely increase
The clinical manifestations in patients are joint pain stiffness and functional limitation
Among all body joints knee joint is the most commonly affected joint with osteoarthritis and accounts almost for four-fifth of the osteoarthritis burden worldwide
Epidemiological research has shown an encouraging relationship between OA and metabolic syndrome MetS include hypertension dyslipidemia hyperglycemia and obesity Recently metabolic OA has been nominated as the fifth component of MetS
Studies reported that adipokines may contribute to the development of osteoarthritis OA by increasing inflammatory cytokines and growth factors modifying insulin sensitivity and triggering processes that break down cartilage
Studies also reported that hypertension can be linked to osteoarthritis through astherosclerosis which cause subchondral bone ischemia accelerating OA progression
Furthermore researches have linked glucose levels to knee osteoarthritis supporting the possibility of pathophysiological mechanisms such oxidative stress in the chondrocytes and Cartilage-associated production of advanced glycation end products AGEs
Of those aged 60 years and older 10 of men and 13 of women had symptomatic knee OA As the population ages and the prevalence of obesity and overweight generaly rises the percentage of persons affected with symptomatic knee OA will likely increase
The clinical manifestations in patients are joint pain stiffness and functional limitation
Among all body joints knee joint is the most commonly affected joint with osteoarthritis and accounts almost for four-fifth of the osteoarthritis burden worldwide
Epidemiological research has shown an encouraging relationship between OA and metabolic syndrome MetS include hypertension dyslipidemia hyperglycemia and obesity Recently metabolic OA has been nominated as the fifth component of MetS
Studies reported that adipokines may contribute to the development of osteoarthritis OA by increasing inflammatory cytokines and growth factors modifying insulin sensitivity and triggering processes that break down cartilage
Studies also reported that hypertension can be linked to osteoarthritis through astherosclerosis which cause subchondral bone ischemia accelerating OA progression
Furthermore researches have linked glucose levels to knee osteoarthritis supporting the possibility of pathophysiological mechanisms such oxidative stress in the chondrocytes and Cartilage-associated production of advanced glycation end products AGEs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None