Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06610773
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-28
Brief Title:
HUC-MSC for Treatment of High-risk HPV Infection
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effectiveness and Safety of Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of HPV High-risk Infection
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the safety and initial effectiveness of human umbilical cord mesenchymal stem cells in HPV clearance
Detailed Description:
Cervical cancer is one of the most common malignant tumors of the female reproductive system with the highest incidence Nearly 997 of cervical cancer is caused by HPV infection Studies have shown that the persistent infection of high-risk human papillomavirus HR-HPV is an independent risk factor for cervical cancer which can lead to a 250-fold increased risk of high-grade cervical intraepithelial neoplasia CIN In patients with persistent HR-HPV infection for more than 12 months the risk of diagnosis of high-grade squamous intraepithelial lesions of the cervix by 30 months increased to 21 In the process of progression from HPV infection to cervical cancer cervical precancerous lesions namely intraepithelial neoplasia CIN will be experienced Therefore effective control of HPV infection especially the elimination of persistent HR-HPV infection will greatly reduce the incidence of CIN and cervical cancer It is an urgent clinical need to actively intervene in patients with persistent infections for more than one year with a clinical significance at present
Mesenchymal Stem Cells MSCs are a class of pluripotent stem cells derived from the mesoderm and ectoderm of early development which can be easily obtained from a variety of tissue organs having a strong proliferation and multidirectional differentiation potential in vitro hUC-MSCs have a great effect on immune regulation and anti-inflammatory properties with a fewer ethical availability safety issues and a broader prospect in clinical research and application At present many experimental data have proved that MSCs can enhance the clearance of virus by immune cells in vivo and have a certain application prospect in fighting virus infection The purpose of this study was to evaluate the safety and therapeutic efficacy of human umbilical cord mesenchymal stem cells HUC-MSCs in clearing HPV infection and to provide clinical basis for HUC-MSCs to clear HPV infection
Mesenchymal Stem Cells MSCs are a class of pluripotent stem cells derived from the mesoderm and ectoderm of early development which can be easily obtained from a variety of tissue organs having a strong proliferation and multidirectional differentiation potential in vitro hUC-MSCs have a great effect on immune regulation and anti-inflammatory properties with a fewer ethical availability safety issues and a broader prospect in clinical research and application At present many experimental data have proved that MSCs can enhance the clearance of virus by immune cells in vivo and have a certain application prospect in fighting virus infection The purpose of this study was to evaluate the safety and therapeutic efficacy of human umbilical cord mesenchymal stem cells HUC-MSCs in clearing HPV infection and to provide clinical basis for HUC-MSCs to clear HPV infection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None