Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06601842
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-14
Brief Title:
Monitoring and Optimization of Cerebral Perfusion Pressure in Post-cardiac Arrest Patients a Pilot Study
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Monitoring and Optimization of Cerebral Perfusion Pressure in Post-cardiac Arrest Patients a Pilot Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to establish the ICP and CPP monitoring process and analyze the results in post-arrest patients to validate the correlation between direct and non-invasive ICP monitoring indicators to establish a protocol of management of elevated ICP and insufficient CPP in post-arrest care to establish a protocol for personalizing CPP and MAP optimization and to analyze its impact on neuroprognosis
Participants will receive ICP monitoring within 12 hours post-ROSC if meet all inclusion and exclusion criteria
Participants will receive ICP monitoring within 12 hours post-ROSC if meet all inclusion and exclusion criteria
Detailed Description:
Post-resuscitation care after cardiac arrest is an important emergency and critical care issue The post-arrest care after the return of spontaneous circulation has also been incorporated into the chain of survival and resuscitation guidelines After the regain of spontaneous circulation cardiac arrest patients will face the challenges of post-arrest syndrome which includes post-anoxic brain injury myocardial dysfunction systemic ischemia-reperfusion and persistent precipitating causes The hypoxic brain injury will impair the autoregulation of cerebral blood vessels thereby affecting the adjustment of intracranial pressure ICP and causing cerebral edema High-quality post-arrest care including targeted temperature management optimization of hemodynamics and respiratory care control of blood sugar monitoring and treatment of epilepsy etc The goal is to achieve neuroprotective effects and improve patient outcomes
The modalities that currently have more evidence for neurocritical care and neuroprognosis include electroencephalogram EEG monitoring pupillary light reflex brain imaging such as computed tomography CT and magnetic resonance imaging MRI somatosensory evoked potentials SSEP and serum biomarkers such as neuron-specific enolase NSE etc Direct ICP monitoring is not routinely used in cardiac arrest patients due to a lack of clinical experience and concurrent use of antiplatelet medications or anticoagulants The application of ICP monitoring in neurocritical care can be based on the experience of traumatic brain injury ICP monitoring can facilitate early detection determination of treatment strategies and prediction of outcomes Cerebral perfusion pressure CPP can also be obtained by ICP monitoring Current head injury treatment guidelines recommend maintaining CPP at around 60-70 mmHg However there are no current recommendations for CPP standards for post-arrest patients In recent years there have been studies on the utilization of the pressure reactivity index to identify the optimized CPP in patients with traumatic brain injury but not yet applicated in post-arrest patients
This study aims to establish the ICP and CPP monitoring process and analyze the result in post-arrest patients to validate the correlation between direct and non-invasive ICP monitoring indicators to establish a protocol of management of elevated ICP and insufficient CPP in post-arrest care to establish a protocol for personalizing CPP and MAP optimization and to analyze its impact on neuroprognosis
The modalities that currently have more evidence for neurocritical care and neuroprognosis include electroencephalogram EEG monitoring pupillary light reflex brain imaging such as computed tomography CT and magnetic resonance imaging MRI somatosensory evoked potentials SSEP and serum biomarkers such as neuron-specific enolase NSE etc Direct ICP monitoring is not routinely used in cardiac arrest patients due to a lack of clinical experience and concurrent use of antiplatelet medications or anticoagulants The application of ICP monitoring in neurocritical care can be based on the experience of traumatic brain injury ICP monitoring can facilitate early detection determination of treatment strategies and prediction of outcomes Cerebral perfusion pressure CPP can also be obtained by ICP monitoring Current head injury treatment guidelines recommend maintaining CPP at around 60-70 mmHg However there are no current recommendations for CPP standards for post-arrest patients In recent years there have been studies on the utilization of the pressure reactivity index to identify the optimized CPP in patients with traumatic brain injury but not yet applicated in post-arrest patients
This study aims to establish the ICP and CPP monitoring process and analyze the result in post-arrest patients to validate the correlation between direct and non-invasive ICP monitoring indicators to establish a protocol of management of elevated ICP and insufficient CPP in post-arrest care to establish a protocol for personalizing CPP and MAP optimization and to analyze its impact on neuroprognosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None