Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06601452
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-31
Brief Title:
Clinical Trial of Anovulatory Infertility
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Exploring the Biological Basis of Tonifying the Kidney and Regulating the Menstrual Cycle in the Treatment of Anovulatory Infertility Based on the Circadian Rhythm of the Biological Clock
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project aims to study the expression of clock genes and related proteins in follicular fluid and granulosa cells depicting the periodic amplitude and phase changes of biological clock genes and related proteins in women of different ages during the reproductive period and in patients with ovulatory disorders The study compares the periodicity amplitude and phase changes of ClockBmal1-TTFLs-klotho related proteins and genes in PCOS DOR patients and age-matched women with normal ovarian function aiming to identify the key segments of ovarian clock gene period rhythm disorder under different disease states and screen the key time points of clock gene oscillation abnormality Omics analysis of the differences between groups analysis of the relationship between gene transcription translation protein expression metabolites and the expression of clock genes and deduction of the dynamic changes and interaction relationships of the biological processes within the ovaries in regulating ovulatory disorders using the method of reinforcing the kidney and regulating the menstrual cycle This aims to clarify that maintaining the ovarian biological clock period rhythm is an important biological basis for the kidney dominating reproduction The regulation mechanism of the treatment of ovulatory disorders using the method of reinforcing the kidney and regulating the menstrual cycle is explained from the perspective of the ovarian biological clock period rhythm
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None