Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06600945
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-27
Brief Title:
Atracurium Versus Atracurium and Magnesium Sulphate As Adjuvants to Local Anesthetic
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Atracurium Versus Atracurium and Magnesium Sulphate As Adjuvants to Local Anesthetic for Peribulbar Anesthesia in Cataract Surgery
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the effects of adding magnesium sulfate to atracurium with local anesthetic mixture on akinesia of globe and eyelid regarding onset and duration in cataract surgery using peribulbar technique
Detailed Description:
Regional anesthesia is a preferred technique for ophthalmic surgery Its safe inexpensive and provides efficient ocular anesthesia for ophthalmic surgery
Among regional blocks peribulbar block is safe to retrobulbar block due to lesser incidence of series complications such as brain-stem anesthesia globe perfusion and retrobulbar hemorrhage
The effect of non-depolarizing neuromuscular blockers on peribulbar anesthesia has been described in many studies According to these studies the use of atracurium as adjuvant to peribulbar anesthesia provides early onset of akinesia and improves the quality of anesthesia in absence of any adverse effect
Magnesium sulphate is non-competitive N-Methyl-D- Aspartate NMDA antagonism and calcium channel blocker Magnesium has endothelium derived Nitric Oxide induced vasodilation It enhanced the activity of local anesthetic agent and improves the quality of anesthesia
Among regional blocks peribulbar block is safe to retrobulbar block due to lesser incidence of series complications such as brain-stem anesthesia globe perfusion and retrobulbar hemorrhage
The effect of non-depolarizing neuromuscular blockers on peribulbar anesthesia has been described in many studies According to these studies the use of atracurium as adjuvant to peribulbar anesthesia provides early onset of akinesia and improves the quality of anesthesia in absence of any adverse effect
Magnesium sulphate is non-competitive N-Methyl-D- Aspartate NMDA antagonism and calcium channel blocker Magnesium has endothelium derived Nitric Oxide induced vasodilation It enhanced the activity of local anesthetic agent and improves the quality of anesthesia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None