Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06600646
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-12
Brief Title:
Investigating the Role of ATP Production by Airway Epithelium in Patients with Refractory and Unexplained Chronic Cough RCCUCC
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Investigating the Role of ATP Production by Airway Epithelium in Patients with Refractory and Unexplained Chronic Cough RCCUCC
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
APEC
Brief Summary:
Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10 but with wide variations across continents Patients with refractory and unexplained chronic cough RCCUCC often exhibit dysregulated vagal pathways necessitating a neuronal biomarker for targeted treatment ATP involved in the ATPP2X3 pathway may serve as a potential biomarker due to its role in the cough reflex The study aims to discover if ATP production by the airway epithelium is greater in RCCUCC patients compared with healthy controls if the epithelium is a source of ATP whether gene and protein expression related to ATP production differs between these groups and whether ATP release is triggered by mechanical and chemical stimulation Additionally the study seeks to determine if biomarker gene expression signatures can differentiate RCCUCC patients from healthy controls
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None