Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06600295
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-13
Brief Title:
Oncology Undernutrition and Sensoriality Links Mechanisms and Levers for Action
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Oncology Undernutrition and Sensoriality Links Mechanisms and Levers for Action - Study ONDES
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ONDES
Brief Summary:
Cancers of the upper aerodigestive tract account for around 4 of all malignant tumours worldwide Colon and liver cancer are the most common digestive cancers The epidemiology of liver cancer is changing and the number of deaths from liver cancer has increased by 25 worldwide Huang 2022 In France around 19000 cancers of the upper aerodigestive tract and 88000 new cases of digestive cancer are diagnosed each year colon cancer remains the most common Globocan 2020 Patients with these two types of cancer are at particularly high risk of undernutrition Pressoir 2010 Gyan 2018
In cancer patients changes in diet may result from constraints linked to the cancer or possible after-effects but also from personal choices for example adopting a healthier diet Cancer and its treatment lead to changes such as increased nutritional requirements and hypercatabolism or sensory changes taste and smell reducing pleasure and food intake These problems will impair quality of life and intensify undernutrition a major problem in the management of the disease since it increases the risk of complications therapeutic failure and mortality It is estimated that 10-20 of deaths in cancer patients are attributable to the consequences of undernutrition rather than to the disease itself Pressoir 2010 In the VICAN study 41 of patients changed their diet after diagnosis 29 because of changes in taste and 82 to have a healthier diet INCa 2014 These changes were associated with the treatment received the presence of sequelae and anxiety
Taste and smell disorders are common in different types of cancer any solid or haematological type and treatments chemotherapy radiotherapy and surgery De Conno 1989 Heckel 2015 Spotten 2017 van Oort 2018 The mechanisms involved in sensory changes are not fully understood especially in cancer and with different types and treatments Murtaza 2017 Several hypotheses have been proposed altered expression of enzymes of the oral sphere altered expression of sensory receptors Neiers 2021 saliva composition and function Zhu 2021 and impact of the oral microbiota Schwartz 2021a Licandro 2023
The early identification of undesirable effects linked to nutrition and the early or anticipated diagnosis of undernutrition are important issues in the management of cancer patients The pleasure or displeasure produced by food guides desire and eating behaviour The mechanisms involved are linked to hedonic sensations conditioned satiety specific sensory satiety negative alliesthesia and the reward system hedonic system The latter is influenced by the environment and can be consciously controlled with several dimensions liking the patient likes or dislikes a given food and wanting evaluates the desire to consume a given food at a given moment All these parameters together with sensory and dietary learning throughout life habits beliefs and constraints influence food preferences and therefore eating behaviour Individual sensitivities and the personal history of the disease treatment and care pathway sequelae presence of co-morbidities etc must therefore be taken into account when setting up preventive actions for cancer patients It seems important to explore these factors the experience of patients and the consequences for eating behaviour in daily life in order to improve support and communication with healthcare professionals as well as prevention and early detection of undernutrition It would be interesting to conduct more in-depth studies on nutritional status quality of life and changes in taste and smell which in most studies have been considered separately
In cancer patients changes in diet may result from constraints linked to the cancer or possible after-effects but also from personal choices for example adopting a healthier diet Cancer and its treatment lead to changes such as increased nutritional requirements and hypercatabolism or sensory changes taste and smell reducing pleasure and food intake These problems will impair quality of life and intensify undernutrition a major problem in the management of the disease since it increases the risk of complications therapeutic failure and mortality It is estimated that 10-20 of deaths in cancer patients are attributable to the consequences of undernutrition rather than to the disease itself Pressoir 2010 In the VICAN study 41 of patients changed their diet after diagnosis 29 because of changes in taste and 82 to have a healthier diet INCa 2014 These changes were associated with the treatment received the presence of sequelae and anxiety
Taste and smell disorders are common in different types of cancer any solid or haematological type and treatments chemotherapy radiotherapy and surgery De Conno 1989 Heckel 2015 Spotten 2017 van Oort 2018 The mechanisms involved in sensory changes are not fully understood especially in cancer and with different types and treatments Murtaza 2017 Several hypotheses have been proposed altered expression of enzymes of the oral sphere altered expression of sensory receptors Neiers 2021 saliva composition and function Zhu 2021 and impact of the oral microbiota Schwartz 2021a Licandro 2023
The early identification of undesirable effects linked to nutrition and the early or anticipated diagnosis of undernutrition are important issues in the management of cancer patients The pleasure or displeasure produced by food guides desire and eating behaviour The mechanisms involved are linked to hedonic sensations conditioned satiety specific sensory satiety negative alliesthesia and the reward system hedonic system The latter is influenced by the environment and can be consciously controlled with several dimensions liking the patient likes or dislikes a given food and wanting evaluates the desire to consume a given food at a given moment All these parameters together with sensory and dietary learning throughout life habits beliefs and constraints influence food preferences and therefore eating behaviour Individual sensitivities and the personal history of the disease treatment and care pathway sequelae presence of co-morbidities etc must therefore be taken into account when setting up preventive actions for cancer patients It seems important to explore these factors the experience of patients and the consequences for eating behaviour in daily life in order to improve support and communication with healthcare professionals as well as prevention and early detection of undernutrition It would be interesting to conduct more in-depth studies on nutritional status quality of life and changes in taste and smell which in most studies have been considered separately
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None