Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06599970
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-19
Brief Title:
Improving Disease Prevention Strategies by Integrating Socio-spatial Characterization of Human Mobility
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Improving Disease Prevention Strategies of Epidemic Spread by Integrating Socio-spatial Characterization of Human Mobility Environmental Typology and Mathematical Modelling in an Urban System of Cuba
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DI-MOB
Brief Summary:
In contrast to the trend expected based on existing prediction models dengue incidence was historically low during the pandemic mobility restrictions of 2020-2021 in most dengue endemic countries This highlights that current transmission models do not correctly take human mobility into account Within a pilot-study in Cienfuegos South-Central Cuba we will characterise the epidemiological spread and distribution of dengue outbreaks 2012-2025 in districts repeatedly involved in previous dengue outbreaks as initiating case-concentrating or transmission sustaining areas This will be linked with fine-grained mobility data and socio-spatial characterizations of commuting flows and population hubs where people are concentrated during day-time time when transmission happens This information together with entomological and environmental risk-data will be used to i improve the accuracy of mathematical dengue models ii better understand the transmission process and iii inform and improve the design of disease control strategies The project will contribute to much-needed evidence-based guidance for public health actors on improved prevention strategies of epidemics dispersion and where and when to implement control measures
Detailed Description:
Using epidemiological data and human mobility data integrated with other multiple-sourced data this study examines the interplay between disease spread and intra-city mobility within a city
The study is ambi-spective using retro- and prospective routine surveillance data 2012-2025 on dengue cases and Aedes entomological data to describe the fine-scale spatio-temporal characterization of dengue transmission in Cienfuegos municipality
To characterise human mobility within the municipality of Cienfuegos information related to recurrent and seasonal movements will be collected Several types of data will be triangulated to obtain a comprehensive understanding of the populations mobility matrix of human mobility In this way six prospective data collection activities are planned
1 Mobility survey The conduct of a mobility survey with adults The purpose of this survey is to gather prospective information regarding recurrent mobility and retrospective information about seasonal mobility Study subjects include adults elderly and indirectly young children through the specific inclusion of young mothers
2 Student survey Questionnaire about mobility of a sample of students in pre-university and university on recurrent and seasonal mobility
3 School registers Consultation of school registers to capture information on school-related recurrent mobility of children of school-going age
4 Vacation stories Within a two-weeks time after the holidays teachers are always doing a vacation story exercise within their class We will ask the teachers of selected classes in the sentinel schools to group this information on the number of children travelling outside the Cienfuegos municipality during holidays seasonal mobility
5 Workplace register Consultation of workplace registers to capture information on work-related recurrent mobility of adults
6 Call Detail Records Anonymized and grouped information about house-workschool locations of cell phone users obtained from cell phone company recurrent movement
In a third step the above information will be brought into a mathematical model explaining mobility within transmission dynamics which will be validated in a prospective way allowing to identify shortcomings and adjust the model where needed
In a last step the various types of collected data will be assembled and discussed together for the elaboration of potential dengue and integrated control strategies and presented for validation with local stakeholders
The study is ambi-spective using retro- and prospective routine surveillance data 2012-2025 on dengue cases and Aedes entomological data to describe the fine-scale spatio-temporal characterization of dengue transmission in Cienfuegos municipality
To characterise human mobility within the municipality of Cienfuegos information related to recurrent and seasonal movements will be collected Several types of data will be triangulated to obtain a comprehensive understanding of the populations mobility matrix of human mobility In this way six prospective data collection activities are planned
1 Mobility survey The conduct of a mobility survey with adults The purpose of this survey is to gather prospective information regarding recurrent mobility and retrospective information about seasonal mobility Study subjects include adults elderly and indirectly young children through the specific inclusion of young mothers
2 Student survey Questionnaire about mobility of a sample of students in pre-university and university on recurrent and seasonal mobility
3 School registers Consultation of school registers to capture information on school-related recurrent mobility of children of school-going age
4 Vacation stories Within a two-weeks time after the holidays teachers are always doing a vacation story exercise within their class We will ask the teachers of selected classes in the sentinel schools to group this information on the number of children travelling outside the Cienfuegos municipality during holidays seasonal mobility
5 Workplace register Consultation of workplace registers to capture information on work-related recurrent mobility of adults
6 Call Detail Records Anonymized and grouped information about house-workschool locations of cell phone users obtained from cell phone company recurrent movement
In a third step the above information will be brought into a mathematical model explaining mobility within transmission dynamics which will be validated in a prospective way allowing to identify shortcomings and adjust the model where needed
In a last step the various types of collected data will be assembled and discussed together for the elaboration of potential dengue and integrated control strategies and presented for validation with local stakeholders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None