Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06599203
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-07
Brief Title:
Children with Diabetic Ketoacidosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Prognostic Factors in Children with Diabetic Ketoacidosis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the present work we aim to
1 Response to therapy During the management of DKA acid base status glycemia and serum electrolytes are measured frequently to monitor the efficacy of treatment detect complications of DKA and its treatment and to determine resolution of DKA
2 Clinical complication like cerebral injury cerebral edema cognitive impairment acute kidney injury hypokalemia
3 Severity of DKA
1 Response to therapy During the management of DKA acid base status glycemia and serum electrolytes are measured frequently to monitor the efficacy of treatment detect complications of DKA and its treatment and to determine resolution of DKA
2 Clinical complication like cerebral injury cerebral edema cognitive impairment acute kidney injury hypokalemia
3 Severity of DKA
Detailed Description:
Diabetic ketoacidosis DKA is a life-threatening condition especially in individuals with Type 1 diabetes It arises from a severe insulin deficiency resulting in elevated blood glucose levels In reaction the body begins metabolizing fat for energy
which causes the production of ketones Ketone buildup in the blood results in metabolic acidosis which produces symptoms including extreme thirst frequent urination stomach discomfort nausea vomiting disorientation and breath that smells like fruit A chronic autoimmune disease known as Type 1 Diabetes Mellitus T1DM is characterized by the eradication of insulin-producing beta cells in the pancreas Although it may happen at any age it often starts to manifest in childhood or adolescent In T1DM the immune system incorrectly targets and kills the beta cells leading to little or nonexistent insulin production The hormone insulin is essential for controlling blood glucose levels Because of this T1DM patients need lifelong insulin medication in order to survive Excessive thirst frequent urination exhaustion and an increased susceptibility to infections are all typical signs of T1DM The treatment of T1DM entails routine blood glucose monitoring the use of insulin pumps or injections a balanced diet routine physical exercise and the management of additional risk factors for complications DKA is diagnosed based on clinical presentation and biochemical abnormalities including hyperglycemia blood glucose gt200 mgdL venous pH of lt73 or serum bicarbonate less than 15 and the presence of ketones in the blood or urine Ill patients with Type-1 DM should be evaluated for DKA which can coexist with or be triggered by other acute illnesses infection trauma etc There may be a history of polydipsia polyuria polyphagia early anorexia late weight loss fatigue or recurrent infection Patients and parents may also report poor school performance lack of concentration altered mental status and confusion as wellPatients with metabolic acidosis classically display rapid deep breathing Kussmaul respirations The breath may have a fruity odor due to respiratory aceton elimination Neurologic findings range from alert to lethargic and drowsy to comatose correlated with the extent of acidosis In order to treat DKA and prevent life-threatening consequences immediate medical intervention essential DKA calls for intravenous fluids insulin therapy and correction of electrolyte imbalances It is indeed crucial to study Diabetic Ketoacidosis DKA its incidence and the features of hospital admissions in order to understand and improve the management of this condition Delayed treatment altered sensorium lower bicarbonate lower pH elevated urea elevated creatinine higher sodium levels at admission are significant risk factors for mortality among children with diabetic keto acidosis at initial presentation Majority of these factors signify severe disease and this could be aggravated by delay in recognition and treatment Overall mortality among children presenting with DKA as the initial presentation in type 1 Diabetes mellitus is 128 14
which causes the production of ketones Ketone buildup in the blood results in metabolic acidosis which produces symptoms including extreme thirst frequent urination stomach discomfort nausea vomiting disorientation and breath that smells like fruit A chronic autoimmune disease known as Type 1 Diabetes Mellitus T1DM is characterized by the eradication of insulin-producing beta cells in the pancreas Although it may happen at any age it often starts to manifest in childhood or adolescent In T1DM the immune system incorrectly targets and kills the beta cells leading to little or nonexistent insulin production The hormone insulin is essential for controlling blood glucose levels Because of this T1DM patients need lifelong insulin medication in order to survive Excessive thirst frequent urination exhaustion and an increased susceptibility to infections are all typical signs of T1DM The treatment of T1DM entails routine blood glucose monitoring the use of insulin pumps or injections a balanced diet routine physical exercise and the management of additional risk factors for complications DKA is diagnosed based on clinical presentation and biochemical abnormalities including hyperglycemia blood glucose gt200 mgdL venous pH of lt73 or serum bicarbonate less than 15 and the presence of ketones in the blood or urine Ill patients with Type-1 DM should be evaluated for DKA which can coexist with or be triggered by other acute illnesses infection trauma etc There may be a history of polydipsia polyuria polyphagia early anorexia late weight loss fatigue or recurrent infection Patients and parents may also report poor school performance lack of concentration altered mental status and confusion as wellPatients with metabolic acidosis classically display rapid deep breathing Kussmaul respirations The breath may have a fruity odor due to respiratory aceton elimination Neurologic findings range from alert to lethargic and drowsy to comatose correlated with the extent of acidosis In order to treat DKA and prevent life-threatening consequences immediate medical intervention essential DKA calls for intravenous fluids insulin therapy and correction of electrolyte imbalances It is indeed crucial to study Diabetic Ketoacidosis DKA its incidence and the features of hospital admissions in order to understand and improve the management of this condition Delayed treatment altered sensorium lower bicarbonate lower pH elevated urea elevated creatinine higher sodium levels at admission are significant risk factors for mortality among children with diabetic keto acidosis at initial presentation Majority of these factors signify severe disease and this could be aggravated by delay in recognition and treatment Overall mortality among children presenting with DKA as the initial presentation in type 1 Diabetes mellitus is 128 14
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None