Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06598891
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-12
Brief Title:
PAS Balance Training for Parkinson Disease PD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effect of Combined PAS Balance Training on Individuals With PD
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Gait initiation GI difficulty is a common problem in individuals with Parkinsons disease PD often linked to impaired anticipatory postural adjustments APA Currently there are no targeted rehabilitation programs designed specifically for GI-related APA in PD patients Research has shown that while motor learning deficits are common in PD explicit learning is better preserved than implicit learning Therefore a GI-related APA training system using an explicit learning model could be particularly effective for this population
During motor learning long-term potentiation LTP increases the excitability of the primary motor cortex Paired associative stimulation PAS has been demonstrated to induce LTP-like changes in the motor cortex making it a potential priming method to enhance motor learning However the priming effect of PAS targeted at leg muscles and the motor cortex on motor learning related to GI-APA has not been previously studied
The objectives of this study are
1 To investigate the effects of explicit and implicit training on GI-related APA
2 To evaluate the priming effect of PAS on GI-related APA training and the associated plasticity changes in the motor cortex
During motor learning long-term potentiation LTP increases the excitability of the primary motor cortex Paired associative stimulation PAS has been demonstrated to induce LTP-like changes in the motor cortex making it a potential priming method to enhance motor learning However the priming effect of PAS targeted at leg muscles and the motor cortex on motor learning related to GI-APA has not been previously studied
The objectives of this study are
1 To investigate the effects of explicit and implicit training on GI-related APA
2 To evaluate the priming effect of PAS on GI-related APA training and the associated plasticity changes in the motor cortex
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None