Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06598488
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-13
Brief Title:
Beetroot Juice A Natural Boost for Cardiovascular Health in Postmenopausal Women
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Beetroot Juice A Natural Boost for Cardiovascular Health in Postmenopausal Women
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BEETBOOST
Brief Summary:
This study aims to explore the effects of short-term beetroot juice BRJ supplementation on cardiovascular health in post-menopausal women The primary focus is to determine whether BRJ rich in nitrates that increase nitric oxide NO bioavailability can reduce blood pressure at rest and during exercise as well as improve oxygen uptake during maximal exercise Given the increased cardiovascular risk in post-menopausal women due to the loss of estrogens protective effects this research seeks to provide a novel non-pharmacological intervention to enhance cardiovascular function during exercise in this population
Detailed Description:
This study aims to evaluate the short-term effects of beetroot juice BRJ supplementation on blood pressure and oxygen uptake during exercise in post-menopausal women Post-menopausal women are at increased risk of cardiovascular disease due to the loss of estrogen which plays a critical role in nitric oxide NO production a key regulator of blood vessel function and blood pressure BRJ rich in dietary nitrates is converted into NO in the body and may offer a natural means to improve cardiovascular health
The primary objective is to investigate whether short-term BRJ supplementation can reduce resting and exercise blood pressure and enhance oxygen uptake during maximal exercise compared to a placebo The study will also explore the relationship between these cardiovascular responses and blood biomarkers including nitratenitrite levels and inflammatory cytokines
The study design is a randomized double-blind placebo-controlled crossover trial Post-menopausal women will be randomized into either the BRJ or placebo group consuming BRJ or nitrate-depleted juice for 4 days followed by a 7-day washout period before switching to the alternate group Participants will undergo testing to measure blood pressure and oxygen uptake at rest and during exercise at baseline and after each intervention
This research is novel and clinically significant as it explores a non-pharmacological approach to mitigate cardiovascular risks in post-menopausal women By improving cardiovascular function this study aims to offer a new strategy for addressing age- and menopause-related increases in blood pressure and declines in exercise capacity
The primary objective is to investigate whether short-term BRJ supplementation can reduce resting and exercise blood pressure and enhance oxygen uptake during maximal exercise compared to a placebo The study will also explore the relationship between these cardiovascular responses and blood biomarkers including nitratenitrite levels and inflammatory cytokines
The study design is a randomized double-blind placebo-controlled crossover trial Post-menopausal women will be randomized into either the BRJ or placebo group consuming BRJ or nitrate-depleted juice for 4 days followed by a 7-day washout period before switching to the alternate group Participants will undergo testing to measure blood pressure and oxygen uptake at rest and during exercise at baseline and after each intervention
This research is novel and clinically significant as it explores a non-pharmacological approach to mitigate cardiovascular risks in post-menopausal women By improving cardiovascular function this study aims to offer a new strategy for addressing age- and menopause-related increases in blood pressure and declines in exercise capacity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None