Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06598150
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-12
Brief Title:
Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord FMRI in Chronic Hemiparetic Stroke
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke
Detailed Description:
Nearly 85 of stroke survivors experience significant unilateral impairment in upper extremity motor control typically caused by damage to the corticospinal CST and corticoreticular CRT tracts ie the corticofugal tracts Alternative neural pathways such as the contralesional cortico-reticulospinal tract CRST can be recruited to achieve movement of the affected arm and hand but may have undesirable consequences For example the diffuse bilateral branching of reticulospinal neurons can produce abnormal muscle co-activations synergies in the paretic limb and involuntary mirror movements associated reactions between limbs Together these effects create stereotypical movement patterns post-stroke and there is growing interest in novel 34anti-synergy34 interventions to enhance usage of residual CST systems rather than strengthening the CRST Imaging has the potential to become an invaluable tool for evaluating whether rehabilitative strategies can preferentially access CST versus CRST pathways However current functional imaging research has focused on cortical activity and must theoretically infer what pathway is used Structural MRI directly assesses changes in white matter pathways but it is limited to detecting long-term plasticity To guide new interventions there is a critical need to directly evaluate what descending motor pathways are active during movement Thus the overall objective of this study is to generate a novel fMRI dataset in participants with post-stroke hemiparesis capturing neural activity during an innovative isometric shoulder abduction task evaluating differences when abducting the paretic versus non-paretic arm The investigators will acquire multi-echo fMRI data in individuals with post-stroke hemiparesis and age-matched controls hypothesizing that increased reliance on the CRST will cause distinct activation patterns during shoulder abduction with the paretic limb and that this will correlate with individual upper-extremity impairment Upper-Extremity Fugl-Meyer Assessment This work is significant because it will provide direct evidence of descending contralesional motor pathway involvement in post-stroke hemiparesis and demonstrate the utility of neuroimaging for optimizing movements to preferentially engage specific systems and promote desired neural plasticity following injury
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None