Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06596187
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-06
Brief Title:
Differential Assessment of Hypertonia
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Differential Assessment of Hypertonia Related to CNS Impairment
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Spasticity and rigidity are common symptoms of central nervous system injuries such as spinal cord injury and Parkinsons disease and result in distinct patterns of increased resistance during passive joint movements Spasticity is characterized by a velocity-dependent increase in stretch reflexes accompanied by exaggerated tendon responses while rigidity is marked by consistent resistance throughout the range of motion traditionally considered independent of stretch velocity However recent studies suggest that rigidity may also be influenced by stretch velocity This study aims to investigate muscle tone by examining spasticity rigidity and normal muscle function through neural and biomechanical changes Standard clinical tools such as the Modified Ashworth Scale and Unified Parkinsons Disease Rating Scale along with additional assessments like the Myoton and Post-Activation Depression PAD will be employed
Detailed Description:
Spasticity and rigidity are common symptoms resulting from central nervous system injuries eg spinal cord injury and Parkinsons disease During passive joint movement spasticity and rigidity manifest as two distinct patterns of increased resistance Spasticity is a type of hypertonia characterized by a stretch reflex that increases with speed accompanied by exaggerated tendon reflexes Rigidity on the other hand is another form of hypertonia where resistance increases during passive movement and remains consistent throughout the range of motion
The degree of rigidity is traditionally considered independent of stretch velocity which is one of the key differences from spasticity However recent studies have found that rigidity may also increase with stretch velocity Despite attempts to distinguish different types of hypertonia based on stretch velocity these efforts have largely been unsuccessful Many factors influence muscle tone which can be broadly categorized into changes in neural and biomechanical properties The Modified Ashworth Scale and the Unified Parkinsons Disease Rating Scale are the most commonly used clinical tools for assessing spasticity and rigidity Additionally devices such as the Myoton or laboratory parameters like Post-Activation Depression PAD are also used for assessment
The degree of rigidity is traditionally considered independent of stretch velocity which is one of the key differences from spasticity However recent studies have found that rigidity may also increase with stretch velocity Despite attempts to distinguish different types of hypertonia based on stretch velocity these efforts have largely been unsuccessful Many factors influence muscle tone which can be broadly categorized into changes in neural and biomechanical properties The Modified Ashworth Scale and the Unified Parkinsons Disease Rating Scale are the most commonly used clinical tools for assessing spasticity and rigidity Additionally devices such as the Myoton or laboratory parameters like Post-Activation Depression PAD are also used for assessment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None