Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06595758
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-03
Brief Title:
This Study Investigates the Impact of Single Nucleotide Polymorphisms in Genes Involved in the Pharmacokinetics and Toxicity of Doxorubicin DOX in Egyptian Female Patients with Breast Cancer It Also Aims to Explore the Association of Pretreatment Neutrophil to Lymphocyte Ratio to PCR
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Pharmacogenetics on Pharmacokinetics and Toxicity of Doxorubicin in Egyptian Breast Cancer Patients
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the effect of single nucleotide polymorphisms SNPs of genes involved in doxorubicin transport and metabolism on its pharmacokinetics and toxicity in Egyptian breast cancer patients
It also aims to explore the association of pretreatment neutrophil to lymphocyte ratio NLR with pathological complete response pCR
It also aims to explore the association of pretreatment neutrophil to lymphocyte ratio NLR with pathological complete response pCR
Detailed Description:
Plasma concentrations of doxorubicin will be determined and venous blood samples will be obtained from each patient for SNP genotyping of genes involved in doxorubicin transport and metabolism on its pharmacokinetics and toxicity in Egyptian breast cancer patients prospective study
A complete blood count was carried out at baseline for patients receiving neoadjuvant chemotherapy The neutrophil to lymphocyte ratio NLR was calculated as the ratio between the absolute count of neutrophils and the absolute count of lymphocytes retrospective study
A complete blood count was carried out at baseline for patients receiving neoadjuvant chemotherapy The neutrophil to lymphocyte ratio NLR was calculated as the ratio between the absolute count of neutrophils and the absolute count of lymphocytes retrospective study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None