Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06592053
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-09
Brief Title:
Affecting Factors for Chronic Pain After Mastectomy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Affecting Factors for the Incidence of Chronic Pain After Mastectomy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CPMP
Brief Summary:
Chronic post-mastectomy pain CPMP is a significant issue affecting many women after mastectomy Factors like age treatment type and pre-surgery pain can increase the risk of developing this condition By understanding these factors we can work towards better prevention and treatment strategies for CPMP Our study aims to investigate the factors contributing to CPMP and contribute to the existing literature on this important topic
Detailed Description:
Chronic post-mastectomy pain CPMP is a common condition and is a significant clinical problem with a prevalence reported in the literature of up to 50 Approximately 10 of patients experience severe pain which has a significant impact on their quality of life Since mastectomy is a frequently performed procedure this syndrome affects a large number of women Therefore it is important to better understand the factors associated with the development of persistent pain
Several theories have been proposed regarding the development of CPMP including increased peripheral nociceptor sensitivity primary hyperalgesia at the site of injury central neuronal sensitivity central hyperalgesia in spinal and supraspinal regions innervating the injured area and inflammatory changes triggered by the central nervous system Recommended methods to prevent CPMP include careful dissection reduction of inflammatory responses and the use of minimally invasive surgical techniques to prevent peripheral and central neuronal sensitization
Epidemiological studies-both retrospective and prospective-have identified some of these risk factors such as younger age chemotherapy radiotherapy and the presence of preoperative pain or severe acute postoperative pain Unfortunately there are few studies on this topic and the literature needs further support
Our hypothesis in this study is that if investigator can identify the factors that increase chronic pain after mastectomy investigator can take measures against these factors and reduce the development of chronic pain Therefore this study aims to identify the factors contributing to chronic pain after mastectomy
Several theories have been proposed regarding the development of CPMP including increased peripheral nociceptor sensitivity primary hyperalgesia at the site of injury central neuronal sensitivity central hyperalgesia in spinal and supraspinal regions innervating the injured area and inflammatory changes triggered by the central nervous system Recommended methods to prevent CPMP include careful dissection reduction of inflammatory responses and the use of minimally invasive surgical techniques to prevent peripheral and central neuronal sensitization
Epidemiological studies-both retrospective and prospective-have identified some of these risk factors such as younger age chemotherapy radiotherapy and the presence of preoperative pain or severe acute postoperative pain Unfortunately there are few studies on this topic and the literature needs further support
Our hypothesis in this study is that if investigator can identify the factors that increase chronic pain after mastectomy investigator can take measures against these factors and reduce the development of chronic pain Therefore this study aims to identify the factors contributing to chronic pain after mastectomy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None