Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06592027
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-08
Brief Title:
Dexmedetomidine for Attenuation of Pressor Response
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Optimal Dose of Dexmedetomidine for Attenuation of Endotracheal Intubation Pressor Response Using Cardiometry a Randomized Double-blinded Study
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Precedex
Brief Summary:
Direct laryngoscopy and tracheal intubation are usually associated by hemodynamic changes due to increased sympathoadrenal activity which could precipitate serious negative effects in compromised patients The pressor response could be blunted by dexmedetomidine which is a selective alpha 2 agonist which might provide hemodynamic stability during tracheal intubation
Detailed Description:
Various drugs include local anesthetics beta-blockers calcium channel blockers and narcotic analgesics have been tried to blunt the laryngoscopy and intubation response with varied success Dexmedetomidine is a potent and highly selective alpha-2 receptor agonist with sympatholytic sedative amnestic and analgesic properties Its various effects have led to its increasing use for reducing anesthetic and analgesic requirements in the perioperative period It inhibits sympathetic activity thus terminating the pain signals and thereby blunts the pressor response associated with laryngoscopy and endotracheal intubation Electrical cardiometry is recently introduced for assessment of many cardiovascular variables and continuously applicable method of cardiac output CO stroke volume SV and other hemodynamic parameters monitoring Its use is growing because it is non-invasive shows reliability in CO measurements and can be used as a continuous bedside monitor Although different doses of dexmedetomidine 05- 20 μgkg have been used in various studies which suggested its efficacy in blunting the hemodynamic pressor response However no studies to the best of our knowledge had incorporated CO monitoring for detection of minimal hemodynamic changes during laryngoscopy and endotracheal intubation which can be best achieved by using Cardiometry monitor
In this study we will compare two doses of dexmedetomidine for prophylaxis against pressor response of ETI using cardiometry
In this study we will compare two doses of dexmedetomidine for prophylaxis against pressor response of ETI using cardiometry
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None