Ignite Creation Date:
2024-10-26 @ 3:40 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06591104
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-09
Brief Title:
Metabolic Phenotypes of Obesity and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Metabolic Phenotypes of Obesity and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Comparison between the 4 groups of metabolic phenotypes of obesity as regard the presence and frequency of DKD
2 Relation between DKD obesity BMI and metabolic risk factors in patients with type 2 DM
2 Relation between DKD obesity BMI and metabolic risk factors in patients with type 2 DM
Detailed Description:
Diabetes is the major cause of chronic kidney disease in industrialized countries Individuals with diabetes and CKD are at a higher risk of developing End Stage Renal Disease and experiencing cardiovascular death Type 2 DM complications are predicted by low estimated glomerular filtration rate and high urine albumin excretion1
Diabetic kidney disease is the primary cause of kidney failure globally affecting 25 to 40 of persons with diabetes mellitus Early diagnosis of high-risk patients is crucial due to the high-risk of progressive deterioration of kidney function leading to end-stage kidney disease which ultimately requires kidney replacement therapy 2
DKD risk factors include non modifiable factors like age gender race genetics and modifiable factors like obesity and lifestyle Obesity is typically associated with metabolic diseases such as hyperglycemia dyslipidemia and high blood pressure Obesitys impact on renal insufficiency is debated and may be influenced by other metabolic abnormalities3
Metabolic phenotypes of obesity based on the BMI-based categories non-obesity obesity and metabolic status metabolically healthy status or metabolically unhealthy status metabolically Healthy non-obesity MHNO metabolically healthy obesity MHO metabolically unhealthy non-obesity MUNO and metabolically unhealthy obesity MUO3
There is a strong correlation between obesity and the onset and course of chronic kidney disease according to a number of population-based studies the investigators think there are still unsolved issues about the connection between obesity and CKD4
so the study is concerned about detection of the relation between metabolic phenotypes of obesity and Diabetic kidney disease
Diabetic kidney disease is the primary cause of kidney failure globally affecting 25 to 40 of persons with diabetes mellitus Early diagnosis of high-risk patients is crucial due to the high-risk of progressive deterioration of kidney function leading to end-stage kidney disease which ultimately requires kidney replacement therapy 2
DKD risk factors include non modifiable factors like age gender race genetics and modifiable factors like obesity and lifestyle Obesity is typically associated with metabolic diseases such as hyperglycemia dyslipidemia and high blood pressure Obesitys impact on renal insufficiency is debated and may be influenced by other metabolic abnormalities3
Metabolic phenotypes of obesity based on the BMI-based categories non-obesity obesity and metabolic status metabolically healthy status or metabolically unhealthy status metabolically Healthy non-obesity MHNO metabolically healthy obesity MHO metabolically unhealthy non-obesity MUNO and metabolically unhealthy obesity MUO3
There is a strong correlation between obesity and the onset and course of chronic kidney disease according to a number of population-based studies the investigators think there are still unsolved issues about the connection between obesity and CKD4
so the study is concerned about detection of the relation between metabolic phenotypes of obesity and Diabetic kidney disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None