Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06588530
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-06
Brief Title:
PFAS Exposure and Immune Response to Vaccination in Adults
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Exposure to Per- and Polyfluoroalkyl Substances PFAS on Innate and Adaptive Immune Responses to Tetanus-diphtheria Td Vaccination Among Adults in a Community-based Panel Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This clinical trial aims to investigate how exposure to Perfluorononanoic acid PFNA a type of per- and polyfluoroalkyl substance PFAS affects the immune response to the standard tetanus and diphtheria Td vaccine The study focuses on participants from a community with known prior PFNA exposure through contaminated drinking water The main question it aims to answer is
Does exposure to PFNA weaken the bodys initial immune response leading to lower levels of protective antibodies after vaccination
Participants will
Receive Tetanus and Diphtheria Td booster vaccination
Visit the study office 7 times over a 30-day period
Have blood and saliva collected at each study visit
Does exposure to PFNA weaken the bodys initial immune response leading to lower levels of protective antibodies after vaccination
Participants will
Receive Tetanus and Diphtheria Td booster vaccination
Visit the study office 7 times over a 30-day period
Have blood and saliva collected at each study visit
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None