Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06587542
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-04
Brief Title:
Effectivity of Protein Purified Derivative Treatment for Anogenital Warts in HIV Patient
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Comparison of the Response and Pathomechanism of Purified Tuberculin Unit Protein Injection Therapy for Anogenital Warts with and Without HIV Infection
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Warts are a common viral infection of the skin and are prevalent throughout the world with an overall prevalence in the United States estimated at 2-20 The incidence of anogenital warts occurs more frequently in HIV-infected patients with a seven-fold increase in risk compared to patients without HIV infection Available treatments for anogenital warts can only reduce but cannot eradicate HPV infection There are many therapeutic options for treating anogenital warts but none can prevent recurrence Immunotherapy has become one of the best therapeutic options for warts caused by HPV infection because it increases the immune response to HPV infection resulting in remission both in lesions that receive direct and indirect intralesional therapy Immunotherapy acts as a basic principle to enhance cell-mediated immunity for wart clearance Apart from low recurrence regression in immunotherapy for warts due to HPV infection generally occurs without cicatrices so it is a consideration in choosing therapy including anogenital warts Various types of immunotherapy have been used one of which is purified protein derivative which can be used as an alternative therapy option for anogenital warts In a previous case report even though an HIV patient had an abnormal immune system tuberculin protein purified derivative therapy immunotherapy provided a significant clinical response in the form of a reduction in lesion size compared to patients who were not given therapy Research regarding the comparison of the response to tuberculin protein purified derivative therapy in anogenital warts patients with and without HIV infection has never been reported Therefore researchers are interested in examining the comparison of the response to tuberculin purified protein derivative therapy in anogenital warts patients between those with and without HIV infection and knowing the comparison of local and systemic cytokine changes when administering anogenital wart therapy with tuberculin protein purified derivative between those with and without HIV infection
Detailed Description:
Research Design Research on the response to administration of intralesional PPD-2TU therapy in warts to changes in levels of various cytokines locally and systemically
Data Data Collection Techniques and Data Sources The data used is primary data Primary data is the result of examination anogenital warts patients who were then given PP2-TU therapy at varying doses blood serum and histopathological preparations are taken before injection and 3 weeks after the injection
Sample TakingSelection The research sample was anogenital warts patients who were treated at the Infection Polyclinic Sexually Transmitted Hospital Dr Hasan Sadikin Bandung using consecutive sampling for each group 15 anogenital warts patients with and 15 patient without HIV infection were given purified protein derivative injection
Data Validity and Reliability The validity of laboratory examination data can be guaranteed due to inspection Laboratory work is carried out in the clinical pathology and anatomical pathology laboratories of the Hospital Dr Hasan Sadikin who has international standards
Independent variable Patients with anogenital warts Dependent variables Clinical response levels of IFN-α IFN-γ and IL-2 in the blood and tissue
Data Data Collection Techniques and Data Sources The data used is primary data Primary data is the result of examination anogenital warts patients who were then given PP2-TU therapy at varying doses blood serum and histopathological preparations are taken before injection and 3 weeks after the injection
Sample TakingSelection The research sample was anogenital warts patients who were treated at the Infection Polyclinic Sexually Transmitted Hospital Dr Hasan Sadikin Bandung using consecutive sampling for each group 15 anogenital warts patients with and 15 patient without HIV infection were given purified protein derivative injection
Data Validity and Reliability The validity of laboratory examination data can be guaranteed due to inspection Laboratory work is carried out in the clinical pathology and anatomical pathology laboratories of the Hospital Dr Hasan Sadikin who has international standards
Independent variable Patients with anogenital warts Dependent variables Clinical response levels of IFN-α IFN-γ and IL-2 in the blood and tissue
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None