Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06586281
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-29
Brief Title:
Elucidating Shared Mechanisms Contributing to NAFLD and PsA Disease Severity With Guselkumab Therapy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Elucidating Shared Mechanisms Contributing to Non-Alcoholic Fatty Liver Disease NAFLD and Psoriatic Arthritis PsA Disease Severity With Guselkumab Therapy
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
While many studies examine Nonalcoholic fatty liver disease NAFLD little is known about its progression to high-risk nonalcoholic steatohepatitis NASH in PsA patients Shared disease mechanisms may explain the increased severity in PsA This study involves two visits from PsA patients with NAFLD and active disease signs eg swollen joint enthesitis or psoriatic plaque It aims to assess the impact of biological therapies on liver disorders joints and skin in PsA patients
Detailed Description:
Nonalcoholic fatty liver disease NAFLD ranging from benign steatosis to severe nonalcoholic steatohepatitis NASH is increasingly common and linked to cirrhosis Patients with psoriatic arthritis PsA are at higher risk for NAFLD and NASH partly due to methotrexate MTX use which is associated with hepatotoxicity Key cytokines involved in PsA such as TNF IL-17 and IL-23 may also contribute to NAFLD progression
The proposed study aims to explore shared pathogenic pathways in NAFLD and PsA by evaluating the role of IL-1723 through imaging metabolomics and synovial biopsies Ultrasound-guided synovial biopsy a safe and effective method will be used to obtain tissue samples enabling the identification of new molecular signatures and therapeutic targets to improve treatment of joint diseases
The proposed study aims to explore shared pathogenic pathways in NAFLD and PsA by evaluating the role of IL-1723 through imaging metabolomics and synovial biopsies Ultrasound-guided synovial biopsy a safe and effective method will be used to obtain tissue samples enabling the identification of new molecular signatures and therapeutic targets to improve treatment of joint diseases
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None