Official Title: Resveratrol-mediated Changes in Extracellular Vesicle MicroRNA Cargo As a Novel Contributor to Resistance Training-induced Skeletal Muscle Adaptations in Older Adults
Status: NOT_YET_RECRUITING
Status Verified Date: 2024-09
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: No
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: STaR
Brief Summary: The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise resistance training or strength training in adults age 60 and to determine whether circulating vehicles of inter-organ communication extracellular vesicles and their cargo might help explain those responses We will also examine whether resveratrol supplementation improves blood vessel function and cognitive function brain health in response to strength training
Detailed Description: After screening and providing informed consent participants healthy older adults age 60 minimally active will be familiarized with the procedures and undergo pre-testing After pre-testing participants will be assigned to supplement with resveratrol or placebo double-blinded daily while undergoing a strength training intervention Strength training will be performed 3xweek for two 6-week blocks and each visit will be supervised by a member of the study team An additional week of testing will follow each of the two 6-week blocks