Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06585254
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-03
Brief Title:
tVNS in Long COVID-19
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Use of Transcutaneous Vagus Nerve Stimulation in Reducing the Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for MECFS
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A prior open label study has shown that transcutaneous vagus nerve stimulation tVNS can improve the health of some patients with postacute sequelae of SARS-CoV-2 infection PASC severely affected enough to also fulfill criteria for myalgic encephalomyelitis chronic fatigue syndrome MECFS The purpose of this study is to compare two sets of stimulus parameters to determine the one that best improves the health-related quality of life of these patients over a period of 6-weeks Patients using their assigned device for at least 30 of the 42 possible opportunities will receive the best device for an additional 6-week period
Detailed Description:
While the US has officially said the SARS CoV-2 emergency is over the country is left with a residual of patients who continue to experience Post-Acute Sequelae of SARS CoV-2 infection -- PASC Unfortunately despite a major effort to understand PASC via the NIH Researching Covid to Enhance Recovery program no specific treatment has emerged and only a limited number of new trials has been initiated The purpose of this proposal is to perform a clinical trial of noninvasive transcutaneous vagus nerve stimulation tVNS in an attempt to find the best tVNS treatment for these patients
The need for the proposed trial is supported by an earlier open label tVNS trial in 15 PASC patients who also fulfilled the 1994 case criteria for myalgic encephalomyelitischronic fatigue syndrome MECFS but for simplicity CFS The research team chose patients with PASC-CFS for two reasons first CFS following Covid infection is probably the most common subgroup of patients with PASC In the study of 41 PASC patients whose continued symptoms over time lead to their being referred for cardiopulmonary exercise tests 47 fulfilled the 1994 case criteria for the diagnosis of CFS Second the research team limited the tVNS pilot to PASC-CFS to reduce the heterogeneity inherent in the diagnosis of PASC The research team specifically recruited non-hospitalized patients with documented Covid who remained ill with fatigue widespread pain cognitive complaints and post-exertional malaise for at least 6 months after the acute infection thus fulfilling the 1994 case criteria for CFS Importantly the entire study was done remotely without requiring participants to come into the medical center or stop current medical treatments
The research team proposes to extend this study to inform us which of two possible ways of stimulating the vagus is the most effective in improving the health of PASC-CFS patients The study again will be done remotely with the study team having access to large databases of non-hospitalized PASC sufferers After determination that a patient had Covid continued ill with PASC and now fulfills criteria for the diagnosis of CFS the participant will be asked to respond to questionnaires via RedCap as to magnitude of fatigue cognitive dysfunction widespread pain andor post-exertional malaise as well as their functional status Each will then be randomized into Treatment A or B and sent the device for these two treatment limbs with instructions to use the device for 35 min a day in the morning over a 6-week period
During the fifth week of study participation participants will receive a stick-on device as well as instructions via zoom to allow them to use the device to provide data on heart rate variability - an objective measure of treatment success Participants will do this for a 6-minute period in the afternoon and then return the device to the study team
Participants will complete questionnaires on RedCap at the end of the first 6-week phase and return the device to the study team to determine usage Participants will be told they must use their device for at least 30 of the 42 days in order to get access to the device that gave the best clinical outcome for an additional 6-weeks At the end of this second 6-week period participants will again complete questionnaires and return their device to the study team
The need for the proposed trial is supported by an earlier open label tVNS trial in 15 PASC patients who also fulfilled the 1994 case criteria for myalgic encephalomyelitischronic fatigue syndrome MECFS but for simplicity CFS The research team chose patients with PASC-CFS for two reasons first CFS following Covid infection is probably the most common subgroup of patients with PASC In the study of 41 PASC patients whose continued symptoms over time lead to their being referred for cardiopulmonary exercise tests 47 fulfilled the 1994 case criteria for the diagnosis of CFS Second the research team limited the tVNS pilot to PASC-CFS to reduce the heterogeneity inherent in the diagnosis of PASC The research team specifically recruited non-hospitalized patients with documented Covid who remained ill with fatigue widespread pain cognitive complaints and post-exertional malaise for at least 6 months after the acute infection thus fulfilling the 1994 case criteria for CFS Importantly the entire study was done remotely without requiring participants to come into the medical center or stop current medical treatments
The research team proposes to extend this study to inform us which of two possible ways of stimulating the vagus is the most effective in improving the health of PASC-CFS patients The study again will be done remotely with the study team having access to large databases of non-hospitalized PASC sufferers After determination that a patient had Covid continued ill with PASC and now fulfills criteria for the diagnosis of CFS the participant will be asked to respond to questionnaires via RedCap as to magnitude of fatigue cognitive dysfunction widespread pain andor post-exertional malaise as well as their functional status Each will then be randomized into Treatment A or B and sent the device for these two treatment limbs with instructions to use the device for 35 min a day in the morning over a 6-week period
During the fifth week of study participation participants will receive a stick-on device as well as instructions via zoom to allow them to use the device to provide data on heart rate variability - an objective measure of treatment success Participants will do this for a 6-minute period in the afternoon and then return the device to the study team
Participants will complete questionnaires on RedCap at the end of the first 6-week phase and return the device to the study team to determine usage Participants will be told they must use their device for at least 30 of the 42 days in order to get access to the device that gave the best clinical outcome for an additional 6-weeks At the end of this second 6-week period participants will again complete questionnaires and return their device to the study team
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None