Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06584448
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-30
Brief Title:
Drinking Acetate and Stress
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Role of Acetate in Heavy Drinking
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the bodys chemistry Specifically the investigators will be studying relationships of drinking and a stress hormone called cortisol The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels
Detailed Description:
Brain acetate consumption will be measured with a novel method called Deuterium Metabolic Imaging DMI in which sodium acetate that has been labeled with deuterium a non-radioactive isotope of hydrogen is administered intravenously over two hours while Magnetic Resonance Spectroscopy MRS is used to map the appearance of the deuterium in glutamate and glutamine regionally through the brain That combination of glutamate and glutamine called Glx serves as a tag to measure the brains rate of acetate consumption That is the more deuterium appears in Glx the more acetate that part of the brain consumes In the same people investigators will perform structural Magnetic Resonance Imaging MRI for co-registration with the MRI and assess regional brain volumes Investigators will also obtain measures of drinking and stress and will measure participants serum cortisol levels and rates of cortisol turnover Each set of measures will be compared across groups and the measurements of acetate uptake will be compared with all other measures for associations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None