Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06582459
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-08-28
Brief Title:
Efficacy and Safety of High-Flow Nasal Cannula Versus Noninvasive Ventilation for Pulmonary Arterial Hypertension-Associated Acute Respiratory Failure
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Efficacy and Safety of High-Flow Nasal Cannula Versus Noninvasive Ventilation for Pulmonary Arterial Hypertension-Associated Acute Respiratory Failure a Retrospective Cohort Study Stratified by Right Ventricular Dysfunction Severity
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HFCNV-PAH
Brief Summary:
This is a single center retrospective propensity score matching cohort study that explores the efficacy and safety of high flow nasal cannula and non-invasive ventilation in the treatment of acute respiratory failure associated with pulmonary arterial hypertension stratified by the severity of right ventricular dysfunction
The study will compare two groups high flow nasal cannula HFNC and non-invasive ventilation NIV
Main objective heart function parameters eg TAPSE and RVSP Secondary objectives respiratory support success rate defined as the avoidance of endotracheal introduction or death duration hospitalization respiratory support duration length of intensive care unit ICU stay length of hospital stay and in-hospital mortality
This study addresses whether NIV or HFNC should be prioritized for the treatment of acute respiratory failure associated with pulmonary arterial hypertension in patients with severe right ventricular dysfunction who require high flow nasal cannula and non-invasive ventilation
This study is of great significance as it is based on a patient stratification method of right ventricular dysfunction severity to evaluate the effectiveness of HFNC treatment and NIV in PH related ARF patients
The study will compare two groups high flow nasal cannula HFNC and non-invasive ventilation NIV
Main objective heart function parameters eg TAPSE and RVSP Secondary objectives respiratory support success rate defined as the avoidance of endotracheal introduction or death duration hospitalization respiratory support duration length of intensive care unit ICU stay length of hospital stay and in-hospital mortality
This study addresses whether NIV or HFNC should be prioritized for the treatment of acute respiratory failure associated with pulmonary arterial hypertension in patients with severe right ventricular dysfunction who require high flow nasal cannula and non-invasive ventilation
This study is of great significance as it is based on a patient stratification method of right ventricular dysfunction severity to evaluate the effectiveness of HFNC treatment and NIV in PH related ARF patients
Detailed Description:
Study Title Efficiency and Safety of High Flow Nassal Cannula Versus Noninvasive Ventilation for Pulsary Arterial Hypertension Associated Acute Respiratory Failure A Retrospective Cohort Study Stratified by Right Ventricular Dysfunction Severity Background Patients with pulmonary hypertension PH typically have high morbidity and mortality when they develop acute respiratory failure ARF The best method of respiratory support considering the severity of right ventricular RV dysfunction is still uncertain
Main objective heart function parameters eg TAPSE and RVSP Secondary objectives respiratory support success rate defined as the avoidance of endotracheal introduction or death duration hospitalization respiratory support duration length of intensive care unit ICU stay length of hospital stay and in-hospital mortality
Research Design This is a single center retrospective propensity score matching cohort study
The study will compare two groups high flow nasal cannula HFNC and non-invasive ventilation NIV
Significance This study aims to address whether NIV or HFNC should be prioritized for the treatment of acute respiratory failure associated with pulmonary arterial hypertension in patients with severe right ventricular dysfunction who require high flow nasal cannula and non-invasive ventilation
Innovation A patient stratification method based on the severity of right ventricular dysfunction to evaluate the effectiveness of HFNC treatment and NIV in PH related ARF patients
Expected outcome HFNC treatment is equally effective as NIV in treating mild to moderate right ventricular dysfunction NIV may be more beneficial for critically ill patients Assist PH patients with ARF in choosing between HFNC treatment and NIV
Conclusion Our study provides new insights into the comparative performance of HFNC therapy and NIV in patients with PH combined with ARF
Main objective heart function parameters eg TAPSE and RVSP Secondary objectives respiratory support success rate defined as the avoidance of endotracheal introduction or death duration hospitalization respiratory support duration length of intensive care unit ICU stay length of hospital stay and in-hospital mortality
Research Design This is a single center retrospective propensity score matching cohort study
The study will compare two groups high flow nasal cannula HFNC and non-invasive ventilation NIV
Significance This study aims to address whether NIV or HFNC should be prioritized for the treatment of acute respiratory failure associated with pulmonary arterial hypertension in patients with severe right ventricular dysfunction who require high flow nasal cannula and non-invasive ventilation
Innovation A patient stratification method based on the severity of right ventricular dysfunction to evaluate the effectiveness of HFNC treatment and NIV in PH related ARF patients
Expected outcome HFNC treatment is equally effective as NIV in treating mild to moderate right ventricular dysfunction NIV may be more beneficial for critically ill patients Assist PH patients with ARF in choosing between HFNC treatment and NIV
Conclusion Our study provides new insights into the comparative performance of HFNC therapy and NIV in patients with PH combined with ARF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None