Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06581172
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-27
Brief Title:
Significance of Disseminated Intravascular Coagulation Score in Mortality for Children With Shock
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Significance of Disseminated Intravascular Coagulation Score in Mortality for Children With Shock
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Evaluates whether the DIC score as defined according to the International Society of Thrombosis and Hemostasis guidelines is associated with mortality in Children with shock and DIC
Detailed Description:
Disseminated intravascular coagulation DIC is an acquired syndrome characterized by excessive systemic activation of coagulation resulting in both hemorrhage and thrombosis DIC can progress rapidly into lifethreatening multiorgan failure Under normal hemostatic conditions clot formation and resolution are tightly regulated In DIC dysregulated activation of the coagulation system results in a consumptive coagulopathy and microvascular thrombosis DIC is always a secondary process caused by a variety of underlying disorders eg sepsis trauma or malignancy which can cause endothelial tissue damage and procoagulant exposure
This activates the coagulation cascade which promotes fibrin production and deposition and consumption of clotting factors The subsequent consumption of coagulation factors and platelets inhibition of natural anticoagulants and fibrinolysis and fibrin deposition result in the clinical picture of DIC a bleeding diathesis accompanied by microvascular thrombosis that often leads to end-organ damage The International Society of Thrombosis and Hemostasis and the Japanese Association for Acute Medicine scoring systems are useful for detection of the DIC in critically ill pediatric patients The overall incidence of DIC to be 12 using a scoring system comprised of etiologic factors clinical features platelet count prothrombin time fibrinogen and fibrin degradation products FDPs The DIC score easily computed in real-time at the bedside with routine laboratory values is associated with mortality for children with sepsis andshock
Diagnosis of DIC through test of the D-dimer Accordingly testing for Ddimer or FDPs may be helpful for evulating relationship between DIC score and mortality rate among children with shock
This activates the coagulation cascade which promotes fibrin production and deposition and consumption of clotting factors The subsequent consumption of coagulation factors and platelets inhibition of natural anticoagulants and fibrinolysis and fibrin deposition result in the clinical picture of DIC a bleeding diathesis accompanied by microvascular thrombosis that often leads to end-organ damage The International Society of Thrombosis and Hemostasis and the Japanese Association for Acute Medicine scoring systems are useful for detection of the DIC in critically ill pediatric patients The overall incidence of DIC to be 12 using a scoring system comprised of etiologic factors clinical features platelet count prothrombin time fibrinogen and fibrin degradation products FDPs The DIC score easily computed in real-time at the bedside with routine laboratory values is associated with mortality for children with sepsis andshock
Diagnosis of DIC through test of the D-dimer Accordingly testing for Ddimer or FDPs may be helpful for evulating relationship between DIC score and mortality rate among children with shock
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None