Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06580977
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-05-03
Brief Title:
Exploring the Effects of Exercise on Memory and Cognition in Parkinsons Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Exploring the Effects of Exercise on Memory and Cognition in Parkinsons Disease
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EMCo
Brief Summary:
The study aims to assess the effects of cardiovascular aerobic training on memory formation and cognitive function in people with Parkinsons disease Participants will be randomly allocated to one of two groups either performing cardiovascular training experimental group or stretching control group for twelve weeks three times a week The primary aim is to examine whether moderate-intense cardiovascular training MICT improves procedural memory formation primary outcome compared to stretching Secondary outcomes include episodic memory formation cognitive function cardiorespiratory fitness sleep quality and brain-derived neurotrophic factor BDNF blood concentration levels
Detailed Description:
Besides the disabling cardinal motor symptoms non-motor symptoms are a common clinical feature of Parkinsons disease PD These non-motor symptoms include amongst others cognitive decline and memory deficits A growing body of evidence suggests that cardiovascular training has the potential to induce functional and structural brain changes that can translate into improved cognitive function including memory While data is mainly derived from studying rodents and healthy populations cardiovascular exercise might also counteract cognitive decline and memory deficits in people with Parkinsons disease pwPD Therefore the primary aim of the study is to investigate the effects of a twelve-week cardiovascular training on memory formation in pwPD
In a randomized controlled trial 60 persons with mild to moderate PD ie Hoehn Yahr 3 will either perform moderate-intensity cardiovascular training experimental group or stretching control group for twelve weeks three times per week totaling 36 training sessions duration per training session 30 to 55 min Participants will perform a procedural memory task before and after the intervention to analyze the effects on non-declarative memory formation primary outcome In addition secondary and exploratory analyses will include the assessment of episodic memory formation cognitive function cardiorespiratory fitness sleep quality and BDNF blood concentration levels The findings of the present study contribute to the current discussion on the neuroplastic effects of cardiovascular training and may have important implications for neurorehabilitation in pwPD
In a randomized controlled trial 60 persons with mild to moderate PD ie Hoehn Yahr 3 will either perform moderate-intensity cardiovascular training experimental group or stretching control group for twelve weeks three times per week totaling 36 training sessions duration per training session 30 to 55 min Participants will perform a procedural memory task before and after the intervention to analyze the effects on non-declarative memory formation primary outcome In addition secondary and exploratory analyses will include the assessment of episodic memory formation cognitive function cardiorespiratory fitness sleep quality and BDNF blood concentration levels The findings of the present study contribute to the current discussion on the neuroplastic effects of cardiovascular training and may have important implications for neurorehabilitation in pwPD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None