Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06580431
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-28
Brief Title:
Trimethylamine N-oxide TMAO Levels in Periodontal Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Trimethylamine N-oxide TMAO Levels in Periodontal Disease
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Salivary and serum levels of TMAO and TNF-A can distinguish between individuals with periodontitis and periodontally healthy persons including smoking and nonsmoking patients
Detailed Description:
Tobacco use is a prevalent global habit with notable impacts on general health and periodontal disease Trimethylamine N-oxide TMAO is a compound involved in the pathogenesis of various systemic inflammatory diseases including cardiovascular conditions The aim of this study was to determine differences in saliva and serum levels of TMAO between periodontitis and periodontally healthy patients according to smoking status
The study includes four groups systemically and periodontally healthy non-smokers NS- Control n 25 systemically healthy non-smokers with Stage-III Grade-B periodontitis NS- Periodontitis n 25 systemically and periodontally healthy smokers S-Control n 25 and systemically healthy smokers with Stage-III Grade-C periodontitis S-Periodontitis n 25 Periodontal parameters were recorded TMAO levels were determined in saliva and serum samples using liquid chromatography-mass spectrometry LC-MSMS TNF-α levels were measured by ELISA method
The study includes four groups systemically and periodontally healthy non-smokers NS- Control n 25 systemically healthy non-smokers with Stage-III Grade-B periodontitis NS- Periodontitis n 25 systemically and periodontally healthy smokers S-Control n 25 and systemically healthy smokers with Stage-III Grade-C periodontitis S-Periodontitis n 25 Periodontal parameters were recorded TMAO levels were determined in saliva and serum samples using liquid chromatography-mass spectrometry LC-MSMS TNF-α levels were measured by ELISA method
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None