Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06580145
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-29
Brief Title:
Leucine in Midlife Depression
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Leucine As a Probe of Kynurenine-Induced Glutamate and Neural Circuit Dysfunction in Midlife Depression
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to investigate the effects of a 6-week leucine challenge on brain chemistry connectivity and behavior in people with midlife depression
The researchers will compare the leucine and an active comparator arm lysine for 6 weeks
The researchers will compare the leucine and an active comparator arm lysine for 6 weeks
Detailed Description:
Major depression is a common and serious mental health condition that can severely impact a personamp39s quality of life Some symptoms like loss of pleasure in activities and slowed movements may be signs that the depression will be harder to treat These symptoms are also linked to a higher risk of dementia later in life
Scientists think that long-term low-level inflammation in the body may contribute to depression especially in middle-aged adults This inflammation may affect areas of the brain involved in feeling good and controlling movement
One way inflammation might lead to depression is through a process in the body called the kynurenine pathway When activated by inflammation this pathway can produce substances that are toxic to brain cells These toxins can disrupt how brain cells communicate and function
Leucine a nutrient found in some foods may help block these toxic substances from entering the brain While animal studies have shown promise we donamp39t yet know if leucine can help humans with depression
To find out researchers are planning a 6-week study in middle-aged adults with depression and signs of inflammation Half the participants will take leucine supplements while the other half will take a different supplement lysine for comparison The study will use brain scans and symptom assessments to see if leucine improves brain function and reduces depression
If successful this research could point to new ways to treat depression especially in cases that donamp39t respond well to current treatments It may also help reduce the risk of dementia in people with depression This study is an important step in understanding how inflammation affects mental health and in developing new treatments to help people feel better
Scientists think that long-term low-level inflammation in the body may contribute to depression especially in middle-aged adults This inflammation may affect areas of the brain involved in feeling good and controlling movement
One way inflammation might lead to depression is through a process in the body called the kynurenine pathway When activated by inflammation this pathway can produce substances that are toxic to brain cells These toxins can disrupt how brain cells communicate and function
Leucine a nutrient found in some foods may help block these toxic substances from entering the brain While animal studies have shown promise we donamp39t yet know if leucine can help humans with depression
To find out researchers are planning a 6-week study in middle-aged adults with depression and signs of inflammation Half the participants will take leucine supplements while the other half will take a different supplement lysine for comparison The study will use brain scans and symptom assessments to see if leucine improves brain function and reduces depression
If successful this research could point to new ways to treat depression especially in cases that donamp39t respond well to current treatments It may also help reduce the risk of dementia in people with depression This study is an important step in understanding how inflammation affects mental health and in developing new treatments to help people feel better
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None