Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06580028
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-28
Brief Title:
The EEG Study Under Sevoflurane Anesthesia in Children
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Electroencephalogram Study in Children Under Sevoflurane Anesthesia - a ProspectiveObservational Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sevoflurane is one of the most commonly used volatile anesthetics in children because of its rapid induction recovery and recovery properties Clinical studies using noninvasive brain monitoring have shown that general anesthetics and hypnotics generate electroencephalogram EEG oscillations in specific spatial tissues that are fundamentally related to the structure and function of neural circuits Slow-wave-delta 01-4 Hz oscillations were present in children of all ages and the advantage of frontal α-wave oscillations appeared at approximately 6 months began to be consistent at 10 months and persisted at older ages Another study which analyzed EEG under sevoflurane general anesthesia in children aged 0-6 months found that Theta and alpha wave power decreased with a decrease in sevoflurane concentrations in infants between 4 and 6 months of recovery However these studies lack detailed characterization of the neural circuit activity associated with anesthesia especially at specific developmental ages that are highly correlated with brain plasticity The aim of this study was to explore electroencephalogram EEG of children of different ages under sevoflurane general anesthesia including anesthesia induction maintenance and recovery By analyzing these EEG data in detail we hope to be able to better understand the EEG characteristics of children of different ages under sevoflurane anesthesia and thus develop a neurophysiology pediatric anesthesia status monitoring strategy
Detailed Description:
This study is prospective and observational Children under sevoflurane general anesthesia were divided into 14 groups 0-3 months old 3-6 months old 6-9 months old 9-12 months old 1-15 years old 15-2 years old 2-25 years old 25-3 years old 3-35 years old 35-4 years old 4-45 years old 455 years old 555 years old 55-6 years old there were 20 cases in each group Inform the family about the research plan and obtain informed consent To observe the time-frequency characteristics of prefrontal electroencephalogram EEG in children of different ages under general anesthesia with sevoflurane
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None