Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06576804
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-20
Brief Title:
Eccentric Cycling Exercise on Mitochondrial Function of Lymphocyte
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Concentric and Eccentric Exercise Regimens on Bioenergetic Efficiency of Lymphocytes in Sedentary Males
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Eccentric cycling exercise ECE features lower metabolic demand and higher improvement of muscle strength compared to traditional concentric cycling exercise CCE Mitochondria can regulate energy metabolism and adaptive immune quality in T lymphocytes However the effects of ECE on mitochondrial functions in T-lymphocytes have not yet been established
Method A total of 33 healthy sedentary males were randomized and divided into ECE n11 CCE n11 and control groups n11 These subjects progressively performed CCE or ECE from 60 to 80 maximal workload on a bicycle ergometer for 40 minday 5 daysweek for 6 weeks A graded exercise testing and an isokinetic strength test were conducted to evaluate cardiopulmonary fitness and muscle strength respectively Phenotypes and mitochondrial respiratory capacity in T lymphocyte were analyzed using flow cytometry and high-resolution respirometer respectively
Method A total of 33 healthy sedentary males were randomized and divided into ECE n11 CCE n11 and control groups n11 These subjects progressively performed CCE or ECE from 60 to 80 maximal workload on a bicycle ergometer for 40 minday 5 daysweek for 6 weeks A graded exercise testing and an isokinetic strength test were conducted to evaluate cardiopulmonary fitness and muscle strength respectively Phenotypes and mitochondrial respiratory capacity in T lymphocyte were analyzed using flow cytometry and high-resolution respirometer respectively
Detailed Description:
Eccentric exercise training EET increases physical performance while having lower metabolic demand than concentric exercise training CET
Mitochondria of lymphocytes are essential for cell proliferation death and differentiation and play a critical role in establishing lymphocyte phenotypes and their functions
Whether EET influences lymphocyte bioenergetic efficiency remains unclear The study was to investigate the effects of ECE and CCE regimens on adaptive immune functions and mitochondrial bioenergetics of T lymphocytes in sedentary males
Mitochondria of lymphocytes are essential for cell proliferation death and differentiation and play a critical role in establishing lymphocyte phenotypes and their functions
Whether EET influences lymphocyte bioenergetic efficiency remains unclear The study was to investigate the effects of ECE and CCE regimens on adaptive immune functions and mitochondrial bioenergetics of T lymphocytes in sedentary males
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None