Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06576440
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
None
First Post:
2024-08-21
Brief Title:
Effects of Ghrelin Administration on Motivation
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effects of Ghrelin Administration on Motivation and Resting Energy Expenditure
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Everyday humans are confronted with a plethora of rewards competing for their attention Nevertheless to obtain a goal or reward humans often need to invest effort When humans are confronted with the challenge to integrate costs of action such as the effort of walking to ones favorite lunch place with its anticipated benefits ie eating ones favorite meal accumulating evidence suggest that humans might go with the gut Ghrelin is a stomach-derived hormone and the only known circulating peptide that stimulates appetite At the same time patients with major depressive disorder report deficits in motivated behavior which are oftentimes accompanied by changes in appetite and weight Based on a wealth of accruing evidence from animal studies the investigators suggest that the gut acts as an important arbitrator in effort allocation by signaling the energy level of the body Within this physiological framework ghrelin is thought to signal a short-term energy deficit to increase reward responsivity and willingness to work for reward as compensatory allostatic means Here the investigators propose to conduct a follow-up study to NCT05318924 with subcutaneous administration of ghrelin vs saline in patients with major depressive disorder and healthy control participants During each visit participants will receive a subcutaneous administration of either ghrelin or saline and perform an effort allocation task where they have to exert physical effort to obtain food and monetary rewards The investigators hypothesize that ghrelin will increase the motivation to exert effort for rewards The goal of this follow-up study is to test that the motivational effects of ghrelin are similar in patients with depression and healthy control participants Furthermore participants resting energy expenditure will be estimated before and after the administration In line with a role of ghrelin as an energy deficit signal the investigators expect ghrelin to decrease energy expenditure During each visit participants will answer questions about their current mood and physiological state The investigators hypothesize that ghrelin increases mood state and hunger while decreasing satiety
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None