Ignite Creation Date:
2024-10-26 @ 3:39 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06574594
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-21
Brief Title:
Effect of MTX Discontinuation on Shingrix Response in RA
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effect of Methotrexate Discontinuation on Immunogenicity of Shingrix in Patients With Rheumatoid Arthritis
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to learn if methotrexate discontinuation affect on immunogeneity of shingrix in RA patients The main questions it aims to answer are
Discontinuation of methotrexate after shingrix immunization increase efficacy of the vaccine in patients with RA
Researchers will compare humoral and cell-mediated immunity against herpes zoster in RA patients who are vaccinated by shingrix and compare these immunity between RA patients with MTX discontinuation and MTX continuation groups
Participants will
Vaccinated with shingrix twice MTX continuation group will keep taking MTX after shingrix vaccination whereas MTX discontinuation group will stop MTX for 2 weeks after shingrix vaccination
Visit the clinic at baseline first shingrix vaccination 2 months later for 2nd shingrix vaccination then 3 6 months later from baseline to achieve blood sample
Discontinuation of methotrexate after shingrix immunization increase efficacy of the vaccine in patients with RA
Researchers will compare humoral and cell-mediated immunity against herpes zoster in RA patients who are vaccinated by shingrix and compare these immunity between RA patients with MTX discontinuation and MTX continuation groups
Participants will
Vaccinated with shingrix twice MTX continuation group will keep taking MTX after shingrix vaccination whereas MTX discontinuation group will stop MTX for 2 weeks after shingrix vaccination
Visit the clinic at baseline first shingrix vaccination 2 months later for 2nd shingrix vaccination then 3 6 months later from baseline to achieve blood sample
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None