Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06570837
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-22
Brief Title:
Iron Deficincy Among Children With type1 DM in Assiut University Hospital
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Iron Deficincy Among Children With type1 DM in Assiut University Hospital
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
detect the prevelance of anemic and non anemic iron deficiency in children with type 1 diabetesassess the impact of anemic and non anemic iron deficiency in children with type 1 diabetes on their general condition
Detailed Description:
Anemic and non anemic iron deficiency is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic developmentIron deficiency anemia IDA appears to be more common in diabetic patients compared to non-diabetic population Iron deficiency ID and IDA can impair glucose homeostasis in human and may negatively affect glycemic control and predispose to more complications in diabetic patients On the other hand diabetes and its complications are associated with anemia and its correction improves diabetes control and may prevent or delay the occurrence of complications 1 Iron-deficiency anemia is the most common type of anemia It occurs when your body doesnt have enough iron which your body needs to make hemoglobin When there isnt enough iron in your blood the rest of your body cant get the amount of oxygen it needs2 Iron-deficiency anemia may be present without a person experiencing symptoms 3 It tends to develop slowly therefore the body has time to adapt and the disease often goes unrecognized for some time 4 If symptoms present patients may present with the sign of pallor reduced oxyhemoglobin in skin or mucous membranes5 and the symptoms of feeling tired weak dizziness lightheadedness poor physical exertion headaches decreased ability to concentrate cold hands and feet cold sensitivity increased thirst and confusion 67 None of these symptoms or any of the others below are sensitive or specific In severe cases shortness of breath can occur 8 Pica may also develop of which consumption of ice known as pagophagia has been suggested to be the most specific for iron deficiency anemia9
Iron deficiency without anaemia has been associated with
weakness fatigue reduced exercise performance difficulty in concentrating and poor work productivity10
neurocognitive dysfunction including irritability11
fibromyalgia syndrome12
restless legs syndrome13
symptom persistence in patients treated for hypothyroidism14
poor neurodevelopmental outcomes in infants born to mothers with iron deficiency15
Iron-deficiency anemia is confirmed by tests that include serum ferritin serum iron level serum transferrin and total iron binding capacity 16 A low serum ferritin is most commonly found However serum ferritin can be elevated by any type of chronic inflammation and thus is not consistently decreased in iron-deficiency anemia17 Serum iron levels may be measured but serum iron concentration is not as reliable as the measurement of both serum iron and serum iron-binding protein levels 18 The percentage of iron saturation or transferrin saturation index or percent can be measured by dividing the level of serum iron by total iron binding capacity and is a value that can help to confirm the diagnosis of iron-deficiency anemia however other conditions must also be considered including other types of anemia19
Iron deficiency without anaemia has been associated with
weakness fatigue reduced exercise performance difficulty in concentrating and poor work productivity10
neurocognitive dysfunction including irritability11
fibromyalgia syndrome12
restless legs syndrome13
symptom persistence in patients treated for hypothyroidism14
poor neurodevelopmental outcomes in infants born to mothers with iron deficiency15
Iron-deficiency anemia is confirmed by tests that include serum ferritin serum iron level serum transferrin and total iron binding capacity 16 A low serum ferritin is most commonly found However serum ferritin can be elevated by any type of chronic inflammation and thus is not consistently decreased in iron-deficiency anemia17 Serum iron levels may be measured but serum iron concentration is not as reliable as the measurement of both serum iron and serum iron-binding protein levels 18 The percentage of iron saturation or transferrin saturation index or percent can be measured by dividing the level of serum iron by total iron binding capacity and is a value that can help to confirm the diagnosis of iron-deficiency anemia however other conditions must also be considered including other types of anemia19
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None