Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06569511
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-21
Brief Title:
Predictive Value of NT-proBNP on MACEs After Acute Coronary Syndrome
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Predictive Value of NT-proBNP on Major Adverse Cardiovascular Events in Patients With Acute Coronary Syndrome During a 6-month Follow-up
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MACEstdy
Brief Summary:
The role of N-terminal pro-B-type natriuretic peptide NT-proBNP as a cardiac biomarker in predicting short-term major adverse cardiovascular events MACEs in patients with Acute coronary syndrome ACS has been insufficiently reported and remains poorly understood Additionally the relationship between NT-proBNP levels and specific ACS subtypes has not been thoroughly examined Therefore our study investigated the predictive value of high-sensitivity cardiac troponin hs-cTn and NT-proBNP levels on admission for 6-month MACEs in patients who presented to the emergency department ED with ACS and subsequently underwent percutaneous coronary intervention PCI Furthermore we sought to evaluate the association between MACEs and specific ACS subtypes
Detailed Description:
In patients diagnosed with Acute coronary syndrome ACS based on anamnesis clinical findings electrocardiogram ECG andor serum high-sensitivity cardiac troponin hs-cTn level in the emergency department ED blood samples for serum N-terminal pro-B-type natriuretic peptide NT-proBNP value was additionally taken during transfer to the coronary intensive care unit and left ventricular ejection fraction LVEF was calculated by echocardiography before percutaneous coronary intervention PCI In addition demographics age sex and smoking status comorbidities hypertension diabetes mellitus DM andor coronary artery disease CAD initial complaints and diagnoses vital signs systolic blood pressure SBP heart rate HR and peripheral capillary oxygen saturation SpO2 laboratory parameters serum creatinine C-reactive protein and hs-cTn and ACS subtypes ST-elevation Myocardial infarction STEMI non-ST-elevation Myocardial infarction NSTEMI or unstable angina pectoris USAP were obtained during admission GRACE risk score was calculated for each patient on admission using eight variables including age SBP HR and serum creatinine At the end of the 6-month follow-up period LVEF of surviving patients was assessed by control echocardiography The short-term MACEs eg nonfatal ischemic stroke nonfatal myocardial infarction cardiovascular mortality or ED admission due to heart failure were recorded
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None