Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06565715
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-16
Brief Title:
Effect of Remazolam on Hemodynamics During Hepatectomy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effect of Remazolam on Hemodynamics During Hepatectomy Under General Anesthesia Combined With Thoracic Epidural Anesthesia
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is high incidence of hemodynamic instability in patients undergoing hepatectomy with low central venous pressure especially in general anesthesia combined with epidural anesthesia Remazolam a new benzodiazepine has no significant cardiovascular inhibitory effect Investigators hypothesis that remazolam will provide better hemodynamic when compared with propofol in patients undergoing hepatectomy with general anesthesia combined with epidural anesthesia
Detailed Description:
Investigators plan to adopt the following strategies in the clinical study of this project 1 To compare remazolam and propofol during anesthetic induction and maintenance 2 Remazolam group remazolam is administered 03mgkg intravenous for anesthesia induction Propofol group propofol is administered 2mgkg intravenous for anesthesia induction 3 Epidural analgesia is used during perioperative period and remifentanil pump injection is used during the operation to assist the subjects to tolerate the tracheal catheter 4 the haemodynamic instability score Hemodynamic instability score is used to comprehensively evaluate intraoperative hemodynamic status 5 To evaluate the incidence of postoperative complications Through the above strategies investigators further determine the optimization effect of remazolam a novel benzodiazepine drug on intraoperative hemodynamics in patients undergoing low central venous pressure hepatectomy and further lay an empirical foundation for the routine use of remazolam in clinical hepatectomy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None