Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06564155
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-19
Brief Title:
Inturlekin L33 in Ankylosing Spondylities Patients and Its Relation to Subclinical Atherosclerosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Inturlekin 33 in Ankylosing Spondylitis Patients and Its Relationship to Subclinical Atherosclerosis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
detect level of Inturlekin 33 in ankylosing spondyilits patient
measure CIMT carotid intima media thickness by carotid duplex to detect subclinical atherosclerosis in ankylosing spondyitis patients
detect the relation between IL33 and subclinical atherosclerosis in Ankylosinig Spondylitis patients
measure CIMT carotid intima media thickness by carotid duplex to detect subclinical atherosclerosis in ankylosing spondyitis patients
detect the relation between IL33 and subclinical atherosclerosis in Ankylosinig Spondylitis patients
Detailed Description:
Ankylosing spondylitis AS a type of SpA is an autoimmune disease that mainly involves sacroiliac joints SIJs and their adjacent soft tissues such as tendons and ligaments The main clinical manifestations include back pain and progressive spinal rigidity as well as inflammation of the hips shoulders peripheral joints and fingerstoes In addition there are extra-articular manifestations
Cardiovascular disease has become the first cause of death for patients with ankylosing spondylitis AS
Patients with ankylosing spondylitis AS have an increased cardiovascular morbidity and mortality Accelerated atherosclerosis caused by a systemic inflammatory response has been reported to be an important risk factor for increased cardiovascular risk for autoimmune diseases
Interleukin IL-33 is a cytokine belonging to the IL-1 family and was recently identified as a ligand for ST2 the serum levels of IL-33sST2 were remarkably higher in the patients with AS than the healthy groups
Pervious studies confirm the importance of IL-33ST2 axis in the process of atherosclerosis and indicate its ambiguous function in immune response whether as proinflammatory cytokine in advanced atherosclerotic lesions or as profibrotic in early lesions
Previous study shows increased CIMT in AS patients without traditional cardiovascular risk factors compared to healthy controls
Cardiovascular disease has become the first cause of death for patients with ankylosing spondylitis AS
Patients with ankylosing spondylitis AS have an increased cardiovascular morbidity and mortality Accelerated atherosclerosis caused by a systemic inflammatory response has been reported to be an important risk factor for increased cardiovascular risk for autoimmune diseases
Interleukin IL-33 is a cytokine belonging to the IL-1 family and was recently identified as a ligand for ST2 the serum levels of IL-33sST2 were remarkably higher in the patients with AS than the healthy groups
Pervious studies confirm the importance of IL-33ST2 axis in the process of atherosclerosis and indicate its ambiguous function in immune response whether as proinflammatory cytokine in advanced atherosclerotic lesions or as profibrotic in early lesions
Previous study shows increased CIMT in AS patients without traditional cardiovascular risk factors compared to healthy controls
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None