Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06561191
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-15
Brief Title:
Functionality of Albumin in the Context of Hemodialysis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Dialyzer Characteristics and Dialysis Mode on Functional Properties of Albumin in Patients With Chronic Hemodialysis Treatment
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FACED
Brief Summary:
Hemodialysis treatment enables patients with end-stage chronic kidney disease to survive At the same time however this treatment also increases cardiovascular mortality in particular due to a chronically increased level of inflammation and usually incomplete removal of uraemic toxins Both of these are closely linked with the functional properties of albumin
The aim of this study is to investigate the effects of various parameters of dialysis in particular dialyzer properties and dialysis mode on the functional properties of albumin and to what extent these parameters can be used therapeutically to improve the treatment quality of hemodialysis treatment in the long term by modifying albumin functional properties
Our own preliminary work in this field and the current state of research indicate that for example the use of high-flux dialyzers can contribute to a reduction of the oxidative stress level It also appears possible that treatment mode haemodiafiltration instead of haemodialysis may also have an effect on the binding and detoxification efficiency of albumin and thus on the removal of uraemic toxins
Previous results have mostly been collected in observational studies As a proof-of-concept study this study will further investigate the concrete therapeutic applicability in an interventional study design
The aim of this study is to investigate the effects of various parameters of dialysis in particular dialyzer properties and dialysis mode on the functional properties of albumin and to what extent these parameters can be used therapeutically to improve the treatment quality of hemodialysis treatment in the long term by modifying albumin functional properties
Our own preliminary work in this field and the current state of research indicate that for example the use of high-flux dialyzers can contribute to a reduction of the oxidative stress level It also appears possible that treatment mode haemodiafiltration instead of haemodialysis may also have an effect on the binding and detoxification efficiency of albumin and thus on the removal of uraemic toxins
Previous results have mostly been collected in observational studies As a proof-of-concept study this study will further investigate the concrete therapeutic applicability in an interventional study design
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None