Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06559280
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-11
Brief Title:
The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Subclinical Doses of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy a Prospective Double-blind Randomized Controlled Clinical Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The experiment aims to explore the clinical effect of subclinical doses of ketamine on early postoperative pain sensitivity in ectopic pregnancy population
Detailed Description:
Ectopic pregnancy EP refers to the implantation and development of a fertilized egg outside the uterine cavity and is one of the common acute abdominal conditions in obstetrics and gynecology Among them tubal pregnancy is the most common type with the highest incidence rate among all ectopic pregnancies After falling ill it is easy for patients to experience symptoms such as vaginal bleeding abdominal pain and amenorrhea and even infertility which seriously affects their physical and mental health After diagnosis patients often experience negative emotions such as anxiety fear and depression A history of preoperative anxiety and depression can lower the patients pain threshold leading to poor postoperative pain control In gynecological laparoscopic surgery ectopic pregnancy surgery is also a relatively painful type of surgery and the establishment of pneumoperitoneum during surgery can easily cause postoperative pain and affect the patients prognosis and quality of life And the patients preoperative preparation time is limited leading to a decrease in pain tolerance and an increased demand for postoperative analgesia Therefore the issue of increased postoperative pain sensitivity in patients with ectopic pregnancy deserves attention
Ketamine is an N-methyl-D-aspartate NMDA receptor inhibitor that can effectively inhibit NMDA receptor-mediated central sensitization As an adjuvant analgesic for preventing postoperative hyperalgesia induced by remifentanil it has a definite therapeutic effect Esketamine also known as right ketamine has pharmacological characteristics similar to racemic ketamine while enhancing analgesic and sedative effects helping to reduce perioperative opioid use It has also shown significant advantages in the treatment of pain sensitivity depression and epilepsy However there are relatively few studies on the postoperative pain sensitivity of subclinical doses of ketamine and ectopic pregnancy patients in clinical practice and whether it can improve postoperative pain sensitivity in such patients still needs further research and exploration
Ketamine is an N-methyl-D-aspartate NMDA receptor inhibitor that can effectively inhibit NMDA receptor-mediated central sensitization As an adjuvant analgesic for preventing postoperative hyperalgesia induced by remifentanil it has a definite therapeutic effect Esketamine also known as right ketamine has pharmacological characteristics similar to racemic ketamine while enhancing analgesic and sedative effects helping to reduce perioperative opioid use It has also shown significant advantages in the treatment of pain sensitivity depression and epilepsy However there are relatively few studies on the postoperative pain sensitivity of subclinical doses of ketamine and ectopic pregnancy patients in clinical practice and whether it can improve postoperative pain sensitivity in such patients still needs further research and exploration
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None