Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06559241
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-04
Brief Title:
Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical ThrombectomyRECAST-MT
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy RECAST-MT A Multicenter Randomized Controlled Open-label Blinded Endpoint Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RECAST-MT
Brief Summary:
For patients with acute ischemic stroke caused by large vessel occlusion endovascular thrombectomy has been demonstrated to be the most effective therapy as approximately 90 of the occluded vessels can be recanalized However less than 50 of patients could achieve functional independence and over 15 died 90 days after stroke Although the mismatch of successful recanalization with poor prognosis can be attributed to many factors the infarct core formed during thrombectomy and reperfusion injury after thrombectomy may be among the most important and effective neuroprotective strategies urgently needed
Remote ischemic conditioning RIC is a noninvasive strategy in which one or more cycles of brief and transient limb ischemia confer protection against prolonged and severe ischemia in distant organs In the transient focal cerebral ischemia-reperfusion model the application of remote ischemic conditioning before reperfusion or both before and after reperfusion reduces reperfusion injuries and the final infarct size Because patients with acute ischemic stroke who are treated with endovascular thrombectomy can achieve a high rate of recanalization after focal ischemia this patient population is akin to the model of transient focal cerebral ischemia-reperfusion Furthermore a pilot study has determined the safety and feasibility of remote ischemic conditioning in patients undergoing endovascular thrombectomy However whether remote ischemic conditioning could provide clinical benefits to patients with acute ischemic stroke who are treated with endovascular thrombectomy urgently needs investigations
This study aims to investigate the safety and efficacy of remote ischemic conditioning in improving functional outcomes of patients with acute ischemic stroke treated with endovascular thrombectomy and explore the effect of treatment duration on the treatment outcome of remote ischemic conditioning
Remote ischemic conditioning RIC is a noninvasive strategy in which one or more cycles of brief and transient limb ischemia confer protection against prolonged and severe ischemia in distant organs In the transient focal cerebral ischemia-reperfusion model the application of remote ischemic conditioning before reperfusion or both before and after reperfusion reduces reperfusion injuries and the final infarct size Because patients with acute ischemic stroke who are treated with endovascular thrombectomy can achieve a high rate of recanalization after focal ischemia this patient population is akin to the model of transient focal cerebral ischemia-reperfusion Furthermore a pilot study has determined the safety and feasibility of remote ischemic conditioning in patients undergoing endovascular thrombectomy However whether remote ischemic conditioning could provide clinical benefits to patients with acute ischemic stroke who are treated with endovascular thrombectomy urgently needs investigations
This study aims to investigate the safety and efficacy of remote ischemic conditioning in improving functional outcomes of patients with acute ischemic stroke treated with endovascular thrombectomy and explore the effect of treatment duration on the treatment outcome of remote ischemic conditioning
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None