Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06554392
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-11
Brief Title:
Identification of Serum Level of Glutathione Peroxidase 4
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Identification of Glutathione Peroxidase 4 in Detecting Ferroptosis in Ankylosing Spondylitis and Axial Psoriatic Arthritis Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Analysis of the level of glutathione peroxidase 4 GPX4 in ankylosing spondylitis and axial psoriatic arthritis patients
The association of glutathione peroxidase 4 GPX4 with disease activity and severity in ankylosing spondylitis and axial psoriatic arthritis patients
The association of glutathione peroxidase 4 GPX4 with disease activity and severity in ankylosing spondylitis and axial psoriatic arthritis patients
Detailed Description:
Ferroptosis first reported by Dixon et al in 2012 is a form of non-apoptotic cell death driven by iron-dependent lipid reactive oxygen species ROS and accelerated by the accumulation of lipid peroxides ultimately leading to oxidative damage to phospholipid membranes and cell death
Ferroptosis could be induced by iron metabolism disorder lipid peroxidation accumulation deficiency of glutathione GSH and inactivation of the antioxidant enzyme glutathione peroxidase 4 GPX4
The morphological features of ferroptotic cells manifest as an aberrant mitochondrial ultrastructure including a reduction in mitochondrial volume an increase in mitochondrial membrane density and the disappearance of mitochondrial cristae in ferroptotic cells
Recent studies have increasingly reported on complex associations between ferroptosis and the immune system The regulatory activity of ferroptosis in immune function and inflammation is multifaceted and involves innate acquired and autoimmunity
Accumulating evidence in recent times has shown an association of ferroptosis with the pathogenesis and development of autoimmune diseases
Spondyloarthropathy comprises a group of chronic inflammatory rheumatic diseases including ankylosing spondylitis reactive arthritis Reiter syndrome arthritis or spondylitis associated with inflammatory bowel disease and psoriatic arthritis as well as undifferentiated spondyloarthritis These afflictions predominantly affect the axial skeleton causing pain and stiffness
Currently research on ferroptosis is still in its early stages therefore exploring the pathogenesis of ferroptosis and its role in various diseases and proposing effective and targeted treatment methods have significant theoretical significance and practical value
Ferroptosis could be induced by iron metabolism disorder lipid peroxidation accumulation deficiency of glutathione GSH and inactivation of the antioxidant enzyme glutathione peroxidase 4 GPX4
The morphological features of ferroptotic cells manifest as an aberrant mitochondrial ultrastructure including a reduction in mitochondrial volume an increase in mitochondrial membrane density and the disappearance of mitochondrial cristae in ferroptotic cells
Recent studies have increasingly reported on complex associations between ferroptosis and the immune system The regulatory activity of ferroptosis in immune function and inflammation is multifaceted and involves innate acquired and autoimmunity
Accumulating evidence in recent times has shown an association of ferroptosis with the pathogenesis and development of autoimmune diseases
Spondyloarthropathy comprises a group of chronic inflammatory rheumatic diseases including ankylosing spondylitis reactive arthritis Reiter syndrome arthritis or spondylitis associated with inflammatory bowel disease and psoriatic arthritis as well as undifferentiated spondyloarthritis These afflictions predominantly affect the axial skeleton causing pain and stiffness
Currently research on ferroptosis is still in its early stages therefore exploring the pathogenesis of ferroptosis and its role in various diseases and proposing effective and targeted treatment methods have significant theoretical significance and practical value
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None