Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06552026
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-22
Brief Title:
Intermittent Theta Burst Stimulation on Anhedonia in Depression
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Intermittent Theta Burst Stimulation on Anhedonia of Treatment Resistant Depression and Brian Network Mechanism
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Study comparing the efficacy of two TMS patterns intermittent theta-burst stimulation iTBS and repetitive transcranial magnetic stimulation rTMS in treating anhedonia and their associated brain network mechanisms
Detailed Description:
Anhedonia is a core feature in major depressive disorders severely affecting up to 70 patients and remaining untreated after traditional antidepressants therapies In previous work the investigators provided clinical evidence for the therapeutic efficacy of personalized rTMS in treating anhedonia However the key practical question is whether personalized connectivity-guided iTBS performs comparably to the existing standard rTMS about the clinical efficacy
This study was designed as a double-blind controlled trial to investigate the intervention effect of iTBS stimulation on anhedonia in depressed patients 33 subjects were included 17 participated in conventional 10 Hz-rTMS treatment and 16 in iTBS treatment Using the subjects MRI imaging data of the nucleus accumbens NAcc as a seed point individualized left dorsolateral prefrontal cortex lDLPFC targets were calculated from brain imaging data Patients received once-daily treatment for 15 days
Clinical symptoms behavioral and EEG assessments were performed before and after treatment Clinical assessments included The Hamilton Anxiety Scale HAMA the Hamilton Depression Rating Scale HAMD the Beck Depression Inventory BDI the Temporal Experience of Pleasure Scale TEPS and Apathy Evaluation Scale AES behavioral and EEG data were collected by the Monetary paradigm One month after the end of the intervention follow-up BDI TEPS and AES symptom data were collected by electronic scales This study focused on the analysis of scale behavioral and EEG data of subjects
This study was designed as a double-blind controlled trial to investigate the intervention effect of iTBS stimulation on anhedonia in depressed patients 33 subjects were included 17 participated in conventional 10 Hz-rTMS treatment and 16 in iTBS treatment Using the subjects MRI imaging data of the nucleus accumbens NAcc as a seed point individualized left dorsolateral prefrontal cortex lDLPFC targets were calculated from brain imaging data Patients received once-daily treatment for 15 days
Clinical symptoms behavioral and EEG assessments were performed before and after treatment Clinical assessments included The Hamilton Anxiety Scale HAMA the Hamilton Depression Rating Scale HAMD the Beck Depression Inventory BDI the Temporal Experience of Pleasure Scale TEPS and Apathy Evaluation Scale AES behavioral and EEG data were collected by the Monetary paradigm One month after the end of the intervention follow-up BDI TEPS and AES symptom data were collected by electronic scales This study focused on the analysis of scale behavioral and EEG data of subjects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None