Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06545591
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-04
Brief Title:
Predictive Role of sTREM in Endovascular Thrombectomy Outcomes
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Soluble Soluble Triggering Receptors Expressed on Myeloid Cells sTREM Predict Outcomes in Stroke Patients Receiving Endovascular Thrombectomy
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Soluble triggering receptor expressed on myeloid cells sTREM which reflects microglia activation has been reported closely associated with neuronal injury and neuroinflammation This study is to investigatethe prognostic roles of sTREM sTREM1 and sTREM2 in patients with ischemic stroke who underwent endovascular thrombectomy EVT
Detailed Description:
For acute ischemic stroke the current treatment strategy involves timely recanalization by intravenous thrombolysis and endovascular thrombectomy EVT Patients receiving EVT are more likely to achieve successful revascularization and long--term functional independence compared with those receiving standard medical treatment1 In patients receiving EVT significant predictors of a favorable functional outcome include minor initial stroke severity successful recanalization and shorter onset--to--treatment time However unfavorable outcomes can occur even after early successful recanalization in some casesTriggering receptors expressed on myeloid cells TREM-1 and TREM-2 are a familyof receptors involved in the immune system expressed on a variety of innate cells of the myeloid lineage including microglia sTREM which reflects microglia activation has been reported closely associated with neuronal injury and neuroinflammation We enrolled adult patients with stroke who received EVT with blood sampling immediately before T1 and after EVT T2 and at 24 hours after EVT T3 Non--stroke controls and patients with non--EVT stroke were also enrolled The plasma concentration of sTREM1 and sTREM2 were analyzed by ELISA The medical information image findings and levels of plasma sTREM1 and sTREM2 were analyzed to clarify the association with poor functional outcome modified Rankin Scale 4-6 at 3 months after stroke
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None