Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06541938
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
AIRE-2 Device for Study of Breath Analysis in IBD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
A Feasibility Study to Use a Handheld In-Home Breath Test Device to Measure H2 and CH4 Production From Carbohydrate Fermentation and Its Correlation With Persistent Symptoms in Inflammatory Bowel Disease Patients in Remission
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AIRE-2
Brief Summary:
The goal of this Prospective single-blinded intervention feasibility study is the utilization of the AIRE-2 device and FoodMarble app to elucidate the interplay among diet symptoms and microbial fermentable features in IBD patients with persistent intestinal symptoms and their household controls
AIRE-2 captures exhaled hydrogen and methane and FoodMarble app records breath levels symptoms and dietary intake
The main questions it aims to answer are
1 To assess the feasibility of using the AIRE-2 device FoodMarble mobile app in a cohort of IBD patients and their household controls to collect data on diet symptoms and exhaled H2 and CH4 levels 2
2 To assess the feasibility of using FoodMarbles FODMAP discovery kit protocol in a cohort of IBD patients and their household controls
3 To collect preliminary data on the relation between diet symptoms and exhaled H2 and CH4 levels measured by the AIRE-2 device and FoodMarble app in a cohort of IBD patients and their household controls
4 To explore the correlation between the fecal microbiome sequencing profile with exhaled H2 and CH4 levels diet and symptoms in a cohort of IBD patients and their household controls
You will
1 Record regular diet in the FoodMarble app and collect baseline stool samples
2 You will then take a low FODMAP diet for 24 hours every week and record the diet and symptoms After the diet you will take the FODMAP challenge of Lactose Fructose Sorbitol and Inulin one every week using Sachets provided by FoodMarble company record exhaled breath levels symptoms and collect stool This process will take 4 weeks
3 Visit clinic to submit stool samples
AIRE-2 captures exhaled hydrogen and methane and FoodMarble app records breath levels symptoms and dietary intake
The main questions it aims to answer are
1 To assess the feasibility of using the AIRE-2 device FoodMarble mobile app in a cohort of IBD patients and their household controls to collect data on diet symptoms and exhaled H2 and CH4 levels 2
2 To assess the feasibility of using FoodMarbles FODMAP discovery kit protocol in a cohort of IBD patients and their household controls
3 To collect preliminary data on the relation between diet symptoms and exhaled H2 and CH4 levels measured by the AIRE-2 device and FoodMarble app in a cohort of IBD patients and their household controls
4 To explore the correlation between the fecal microbiome sequencing profile with exhaled H2 and CH4 levels diet and symptoms in a cohort of IBD patients and their household controls
You will
1 Record regular diet in the FoodMarble app and collect baseline stool samples
2 You will then take a low FODMAP diet for 24 hours every week and record the diet and symptoms After the diet you will take the FODMAP challenge of Lactose Fructose Sorbitol and Inulin one every week using Sachets provided by FoodMarble company record exhaled breath levels symptoms and collect stool This process will take 4 weeks
3 Visit clinic to submit stool samples
Detailed Description:
Study Design Type
Prospective single-blinded intervention feasibility study
MethodologyStudy Design
A cohort of IBD patients and their healthy household controls will be recruited for this study You will be instructed to use a handheld breathalyzer device AIRE-2 to measure exhaled H2 and CH4 gas production and its smartphone app FoodMarble will be used to log your diet and symptoms for a period of 5 weeks as follows
AIRE-2 will be used before and after two meals each day - the first meal and the last meal of the day You will breathe into the AIRE-2 device before eating to obtain the baseline value After the meal you will breathe into the AIRE-2 60 minutes postprandially The exhaled H2 and CH4 measurements will be automatically logged into the FoodMarble app which is connected via Bluetooth You will log your food intake and symptoms in FoodMarble Symptoms scores will be recorded at the same time that the AIRE- 2 device is being used - 60 minutes postprandial You will be asked not to drink alcohol during the meals that will be recorded as this will skew the device results You will be informed that you can consume alcoholic drinks after doing the postprandial breath test
Study procedure
1 Study Enrolment and Familiarization Period At visit 1 you will be trained to use the AIRE-2 device which McMaster has purchased from the FoodMarble company and will be provided to you You will also be trained to use the FoodMarble app The FoodMarble company is the owner of the AIRE-2 device which is being used in the present study the company wouldnt have access to resulting data other than publication Demographics medical history disease activity Gastrointestinal symptom rating scale GSRS Bristol stool type medications supplements perceived food intolerances and general dietary patterns will be recorded at baseline We shall assist you in inputting some GI and extra-intestinal symptoms headache foggy mind numbness of joints joint pain fainting oral lesions dermatitis manually in the FoodMarble app from the GSRS symptom questionnaire as all symptoms are not mentioned in the app and there is a provision to edit the symptom list After visit 1 you will have 3 days to use the device and app in order to become familiar with its use and report any challenges and difficulties to us in visit 2 online via McMaster Zoom At the end of the familiarization period you are expected to be comfortable using the AIRE-2 device and the FoodMarble app No data reported during this period will be used for the purpose of analysis or outcomes evaluation
2 Baseline Period This period starts after the familiarization week and runs for one week representing the beginning of the data tracking collection During the baseline period you will eat your normal typical diet while collecting your breath test food and symptoms as described above The baseline period serves to capture the natural fluctuations of breath H2 and CH4 of each individual and to explore the correlations with diet and symptoms You will be instructed to take the breath test before and 60 minutes after two major meals every day You will also collect the baseline stool sample and drop it off at the study location during visit 3 at the end of this period You will be handed the low FODMAP diet chart which will be required in discovery period
3 Discovery Period This period starts after the baseline period and runs for four weeks During this period you will document your responses to challenges with four specific FCHOs- Lactose Fructose Sorbitol and Inulin Food Intolerance Kit FoodMarble Inc Dublin Ireland The quantities of each FCHO challenge are as follows lactose and fructose sachets 25g each A sachet of lactose roughly equal to amount of lactose present in 1 large glass of milk A sachet of fructose is roughly equal to amount of fructose present in 2 large apples Sorbitol and inulin sachets contain 10g each A sachet of sorbitol is roughly equal to the amount of sorbitol present in 3 pears or 1 prune A sachet of inulin is roughly equal to the amount of inulin present in 1 head of garlic Each sachet has to be dissolved in 250 ml of lukewarm water Before each challenge you will follow a low FODMAP diet for 24h to facilitate clearance of any FCHOs from the intestine You will be guided by a registered dietitian RD regarding an appropriate low FCHO diet supported by the FoodMarble app which provides a large database of low FODMAP meals and recipes You will log all meals during the 24h low FCHO period using the FoodMarble app The meals will be analyzed by the RD and scored on a 4-point scale poor moderate good excellent for adherence to the low FCHO diet Exhaled H2 and CH4 will be measured before and 60 min after the first and last meal during this period as usual After the 24h low FCHO diet you will consume one FCHO challenge in the morning after the baseline breath test and take the postprandial breath test 60 min later You will be required to record the breath test for 3 hours after every 15 minutes as per the protocol of the kit You will then collect the first stool sample after the challenge and submit it to us in visit 4 Symptoms and meals will continue to be logged in the FoodMarble app You will also be instructed to fill in a validated questionnaire to assess symptoms before and after the FCHO challenge Adult Carbohydrate Perception Questionnaire This questionnaire will be given to you in paper form A 6-day washout period will be implemented in between the FCHO challenges During the washout period you will follow your typical diet The 24h low Fodmap day FCHO challenge 6-day washout cycle and submission of stool samples visit 4-7 will be repeated until all 4 FCHO challenges have been completed The order of the FCHO challenges will be randomized and will be kept constant between all of you to minimize potential co-founding factors related to the order of the intervention However you will be blinded to the order
4 End of the study At the end of the discovery period you will answer a feedback survey to report their experience using AIRE-2 and FoodMarble
Prospective single-blinded intervention feasibility study
MethodologyStudy Design
A cohort of IBD patients and their healthy household controls will be recruited for this study You will be instructed to use a handheld breathalyzer device AIRE-2 to measure exhaled H2 and CH4 gas production and its smartphone app FoodMarble will be used to log your diet and symptoms for a period of 5 weeks as follows
AIRE-2 will be used before and after two meals each day - the first meal and the last meal of the day You will breathe into the AIRE-2 device before eating to obtain the baseline value After the meal you will breathe into the AIRE-2 60 minutes postprandially The exhaled H2 and CH4 measurements will be automatically logged into the FoodMarble app which is connected via Bluetooth You will log your food intake and symptoms in FoodMarble Symptoms scores will be recorded at the same time that the AIRE- 2 device is being used - 60 minutes postprandial You will be asked not to drink alcohol during the meals that will be recorded as this will skew the device results You will be informed that you can consume alcoholic drinks after doing the postprandial breath test
Study procedure
1 Study Enrolment and Familiarization Period At visit 1 you will be trained to use the AIRE-2 device which McMaster has purchased from the FoodMarble company and will be provided to you You will also be trained to use the FoodMarble app The FoodMarble company is the owner of the AIRE-2 device which is being used in the present study the company wouldnt have access to resulting data other than publication Demographics medical history disease activity Gastrointestinal symptom rating scale GSRS Bristol stool type medications supplements perceived food intolerances and general dietary patterns will be recorded at baseline We shall assist you in inputting some GI and extra-intestinal symptoms headache foggy mind numbness of joints joint pain fainting oral lesions dermatitis manually in the FoodMarble app from the GSRS symptom questionnaire as all symptoms are not mentioned in the app and there is a provision to edit the symptom list After visit 1 you will have 3 days to use the device and app in order to become familiar with its use and report any challenges and difficulties to us in visit 2 online via McMaster Zoom At the end of the familiarization period you are expected to be comfortable using the AIRE-2 device and the FoodMarble app No data reported during this period will be used for the purpose of analysis or outcomes evaluation
2 Baseline Period This period starts after the familiarization week and runs for one week representing the beginning of the data tracking collection During the baseline period you will eat your normal typical diet while collecting your breath test food and symptoms as described above The baseline period serves to capture the natural fluctuations of breath H2 and CH4 of each individual and to explore the correlations with diet and symptoms You will be instructed to take the breath test before and 60 minutes after two major meals every day You will also collect the baseline stool sample and drop it off at the study location during visit 3 at the end of this period You will be handed the low FODMAP diet chart which will be required in discovery period
3 Discovery Period This period starts after the baseline period and runs for four weeks During this period you will document your responses to challenges with four specific FCHOs- Lactose Fructose Sorbitol and Inulin Food Intolerance Kit FoodMarble Inc Dublin Ireland The quantities of each FCHO challenge are as follows lactose and fructose sachets 25g each A sachet of lactose roughly equal to amount of lactose present in 1 large glass of milk A sachet of fructose is roughly equal to amount of fructose present in 2 large apples Sorbitol and inulin sachets contain 10g each A sachet of sorbitol is roughly equal to the amount of sorbitol present in 3 pears or 1 prune A sachet of inulin is roughly equal to the amount of inulin present in 1 head of garlic Each sachet has to be dissolved in 250 ml of lukewarm water Before each challenge you will follow a low FODMAP diet for 24h to facilitate clearance of any FCHOs from the intestine You will be guided by a registered dietitian RD regarding an appropriate low FCHO diet supported by the FoodMarble app which provides a large database of low FODMAP meals and recipes You will log all meals during the 24h low FCHO period using the FoodMarble app The meals will be analyzed by the RD and scored on a 4-point scale poor moderate good excellent for adherence to the low FCHO diet Exhaled H2 and CH4 will be measured before and 60 min after the first and last meal during this period as usual After the 24h low FCHO diet you will consume one FCHO challenge in the morning after the baseline breath test and take the postprandial breath test 60 min later You will be required to record the breath test for 3 hours after every 15 minutes as per the protocol of the kit You will then collect the first stool sample after the challenge and submit it to us in visit 4 Symptoms and meals will continue to be logged in the FoodMarble app You will also be instructed to fill in a validated questionnaire to assess symptoms before and after the FCHO challenge Adult Carbohydrate Perception Questionnaire This questionnaire will be given to you in paper form A 6-day washout period will be implemented in between the FCHO challenges During the washout period you will follow your typical diet The 24h low Fodmap day FCHO challenge 6-day washout cycle and submission of stool samples visit 4-7 will be repeated until all 4 FCHO challenges have been completed The order of the FCHO challenges will be randomized and will be kept constant between all of you to minimize potential co-founding factors related to the order of the intervention However you will be blinded to the order
4 End of the study At the end of the discovery period you will answer a feedback survey to report their experience using AIRE-2 and FoodMarble
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None