Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06540924
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-30
Brief Title:
Investigation of LBX1 TIMP2 GPR126 and CHD7 Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Investigation of LBX1 TIMP2 GPR126 and CHD7 Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Adolescent Idiopathic Scoliosis AIS is a common disease of the spine observed in individuals aged 10-18 who typically do not have any other health issues Despite numerous genetic studies conducted across different ethnic groups worldwide the specific genes contributing to the development of scoliosis have not yet been definitively identified Therefore the aim of our study is to investigate whether there is an etiological relationship between AIS and the polymorphisms of the LBX1 rs11190870 rs625039 rs11598564 TIMP2 rs8179090 GPR126 rs6570507 and CHD7 rs121434341 genes in the Turkish population and to determine the relationship of these polymorphisms with gender age age at diagnosis and Cobb angle in these patients
Detailed Description:
This prospective genetic research was conducted Bursa Uludag University Faculty of Medicine Department of Orthopedics and Traumatology A total of 301 individuals were included in the study comprising 201 patients aged 10-18 years diagnosed with AIS and Cobb angle of 10 degrees or more on direct radiography no known genetic disorders and no diseases known to play a role in the etiology of scoliosis and 100 healthy controls aged 10-18 years without a diagnosis of scoliosis based on physical examination andor imaging In the study the LBX1 TIMP2 GPR126 and CHD7 gene polymorphisms in AIS patients and the control group were analyzed using real-time PCR with TaqMan probe SNP single nucleotide polymorphism primers rs625039 rs11598564 rs6570507 rs121434341 rs11190870 rs8179090 Subsequently the SNP regions were confirmed by DNA sequence analysis The obtained findings were statistically analyzed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None