Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06540573
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-02
Brief Title:
The Relationship Between Serum Chemokine Ligand 21 CCL-21 Level and Disease Activity
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Relationship Between Serum Chemokine Ligand 21 CCL-21 Level and Disease Activity in Patients With Rheumatoid Arthritis and Osteoarthritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Rheumatoid arthritis RA is a chronic systemic disease characterized by the development of new capillaries involved in the infiltration of inflammatory cells causing synovial hyperplasia and progressive destruction of cartilage and boneOsteoarthritis OA is a degenerative joint disease that involves articular cartilage and other intra-articular structuresAlthough the pathological mechanisms involved in OA and RA are different the onset and progression of both diseases are associated with inflammation immune mechanisms and metabolic factorsC-C Motif Chemokine Ligand 21 CCL21 is a CCR7-binding chemokine that plays an important role by modulating the circulation of T cells and dendritic cells in lymphoid and peripheral organs 9 Ligation of CCL21 in RA fibroblasts and macrophages induced the production of proangiogenic factors such as VEGF Ang-1 and IL-8 suggesting that CCL21 plays an indirect role in RA angiogenesisThe aim of our study is to evaluate the serum levels of CCL21 in RA and OA patients by comparing them with healthy controls In addition the aim is to examine the correlation of serum CCL21 with disease degreeseverity in both diseases and to determine whether it can be a biomarker of the disease state
Detailed Description:
Rheumatoid arthritis RA is a chronic systemic disease characterized by the development of new capillaries involved in the infiltration of inflammatory cells causing synovial hyperplasia and progressive destruction of cartilage and bone The synovial tissue layer consists of macrophages and fibroblasts which have profound effects on the destructive process in RA through the production of pro-inflammatory cytokines chemokines and pro-angiogenic factors 23 Osteoarthritis OA is a degenerative joint disease that involves articular cartilage and other intra-articular structures 4 OA leads to pain stiffness decreased joint function 5 and ultimately disability 6 Although the pathological mechanisms involved in OA and RA are different the onset and progression of both diseases are associated with inflammation immune mechanisms and metabolic factors 78 C-C Motif Chemokine Ligand 21 CCL21 is a CCR7-binding chemokine that plays an important role by modulating the circulation of T cells and dendritic cells in lymphoid and peripheral organs 9 Ligation of CCL21 in RA fibroblasts and macrophages induced the production of proangiogenic factors such as VEGF Ang-1 and IL-8 suggesting that CCL21 plays an indirect role in RA angiogenesis 10
We determined that CCL21-mediated RA arthritis extends joint inflammation to bone erosion by coupling the differentiation of M1 macrophages with Th17 cells Disease progression is further exacerbated by CCL21-induced neovascularization We conclude that CCL21 is an attractive new target for the treatment of RA as blocking its function can abolish erosive arthritis modulated by M1 macrophages and Th17 cell crosstalk In short CCL21 is a pleiotropic chemokine that shapes many aspects of RA pathology We have not found a study that examined CCL21 blood serum levels in RA and OA patients and healthy controls and evaluated whether there is a relationship between CCL21 and these diseases
The aim of our study is to evaluate the serum levels of CCL21 in RA and OA patients by comparing them with healthy controls In addition the aim is to examine the correlation of serum CCL21 with disease degreeseverity in both diseases and to determine whether it can be a biomarker of the disease state
We determined that CCL21-mediated RA arthritis extends joint inflammation to bone erosion by coupling the differentiation of M1 macrophages with Th17 cells Disease progression is further exacerbated by CCL21-induced neovascularization We conclude that CCL21 is an attractive new target for the treatment of RA as blocking its function can abolish erosive arthritis modulated by M1 macrophages and Th17 cell crosstalk In short CCL21 is a pleiotropic chemokine that shapes many aspects of RA pathology We have not found a study that examined CCL21 blood serum levels in RA and OA patients and healthy controls and evaluated whether there is a relationship between CCL21 and these diseases
The aim of our study is to evaluate the serum levels of CCL21 in RA and OA patients by comparing them with healthy controls In addition the aim is to examine the correlation of serum CCL21 with disease degreeseverity in both diseases and to determine whether it can be a biomarker of the disease state
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None