Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06539962
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-02
Brief Title:
Interstitial Lung Disease is a Risk Factor for Cardiovascular Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Interstitial Lung Disease is a Risk Factor for Cardiovascular Disease Potential Role for Systemic Biomarkers Krebs Von Den Lungen-6 KL-6
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A group of Interstitial pulmonary fibrosis will be recruited from Assiut university hospital outpatient clinic
Evaluation will be done regarding cardiovascular comorbidities Cardiovascular comorbidities will be evaluated with thorough assessment including history ECG Lipid profile and echocardiography
Lipid profile CRP and KL-6 level will be assessed for recruited personnel Regression analysis will be used to identify risk factors for cardiovascular comorbidities among IPF patients
Evaluation will be done regarding cardiovascular comorbidities Cardiovascular comorbidities will be evaluated with thorough assessment including history ECG Lipid profile and echocardiography
Lipid profile CRP and KL-6 level will be assessed for recruited personnel Regression analysis will be used to identify risk factors for cardiovascular comorbidities among IPF patients
Detailed Description:
Interstitial lung disease ILD is a chronic progressive parenchymal disease of the lungs ILD has been associated with various cardiovascular co-morbidities such as coronary artery disease CAD and heart failure HF So far little is known regarding the cardiovascular co-morbidities in patients with idiopathic pulmonary fibrosis IPF the most aggressive form of ILD
Blood biomarkers have been shown to emerging evidence in patients with IPF in clinical practice Several blood biomarkers including lung-epithelium specific proteins chemokines growth factors proteases and other serological markers have been studied widely in the fields of diagnosis disease severity and prognosis in patients with IPF Among them Krebs von den Lungen-6 KL-6 is used in clinical practice and elevated level of KL-6 is known to predict mortality in patients with IPF
It is well documented that fibrosis is closely linked to the inflammatory response Emerging evidence suggests that cardiac fibrosis in general is primarily due to complications associated with acute and prolonged inflammation suggesting that even low-grade persistent inflammation is enough to promote cardiac fibrosis The cellular and molecular events that underpin the inflammatory processes in cardiac disease are complex and poorly understood with many tissue and disease specific mechanisms
Blood biomarkers have been shown to emerging evidence in patients with IPF in clinical practice Several blood biomarkers including lung-epithelium specific proteins chemokines growth factors proteases and other serological markers have been studied widely in the fields of diagnosis disease severity and prognosis in patients with IPF Among them Krebs von den Lungen-6 KL-6 is used in clinical practice and elevated level of KL-6 is known to predict mortality in patients with IPF
It is well documented that fibrosis is closely linked to the inflammatory response Emerging evidence suggests that cardiac fibrosis in general is primarily due to complications associated with acute and prolonged inflammation suggesting that even low-grade persistent inflammation is enough to promote cardiac fibrosis The cellular and molecular events that underpin the inflammatory processes in cardiac disease are complex and poorly understood with many tissue and disease specific mechanisms
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None