Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06539832
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-22
Brief Title:
Intestinal Flora and Immunity in Monoclonal Gammopathy Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Correlation Analysis of Intestinal Flora and Immune Function in Patients With Monoclonal Immunoglobulinaemia Co-infection
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the characteristics of the gut microbiota and immune function status in patients with monoclonal gammopathy complicated by infection and to analyze the correlation between the two200 patients diagnosed with monoclonal gammopathy by MALDI-TOF MS were included of which 100 had concurrent infections and 100 did not An additional 100 healthy controls matched for age and gender were also enrolledBy comparing the composition of the gut microbiota and immune function markers such as peripheral blood immune cell profiles and cytokine levels between the patient groups and the control group the study will evaluate the dysbiosis of the gut microbiota and abnormal immune status in patients with monoclonal gammopathy complicated by infection The aim is to explore the correlation between the gut microbiome alterations and immune dysfunction in order to provide a basis for further investigation of the underlying mechanisms
Detailed Description:
The intestine is the largest immune organ in the human body playing a crucial role in regulating host health maintaining metabolic and immune homeostasis and preventing pathogen invasion The gut microbiota can directly participate in the immune regulation of the host promote the development of the immune system and maintain normal immune function Meanwhile the immune system also has a regulatory and constraining effect on the gut microbiota With age the structure of the gut microbiota and the function of the immune system undergo continuous changes and adjustments to adapt to the bodys needs This dynamic gut microbiota-immune system interaction plays a key role in maintaining metabolic homeostasis and immune balance in the bodyMultiple myeloma MM is a hematological malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow commonly seen in middle-aged and elderly individuals MM patients generally have a higher risk of infection especially after receiving intensive chemotherapy or hematopoietic stem cell transplantationMonoclonal gammopathy of undetermined significance MGUS is an asymptomatic condition and multiple myeloma often progresses from monoclonal gammopathy Although most MGUS patients do not progress to malignant disease for life MGUS patients do have a higher risk of infection Gut microbiome dysbiosis may be involved in regulating immune function leading to increased susceptibility to infections in MGUS patientsThis study aims to use a retrospective cohort study approach to systematically analyze the characteristics of the gut microbiota in MGUS patients with concurrent infections and explore its correlation with immune-related indicators In-depth analysis of these key factors will help further elucidate the pathogenesis of MGUS complicated by infection and provide new evidence and insights for clinical prevention and treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None